Dntt MGI Mouse Gene Detail - MGI:98659 - deoxynucleotidyltransferase, terminal

Symbol

Dntt
Name

deoxynucleotidyltransferase, terminal
Synonyms

Tdt

Feature Type

protein coding gene
IDs

MGI:98659
NCBI Gene: 21673
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:41017714-41047964 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 34.32 cM
Mapping Data

20 experiments

SNPs within 2kb

1201 from dbSNP Build 142
Strain Annotations

18
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98659	protein coding gene	Chr19:41017701-41047964 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025118	protein coding gene	Chr19:40285982-40318831 (+)
A/J	MGP_AJ_G0025095	protein coding gene	Chr19:38333042-38381157 (+)
AKR/J	MGP_AKRJ_G0025063	protein coding gene	Chr19:39617646-39647465 (+)
BALB/cJ	MGP_BALBcJ_G0025089	protein coding gene	Chr19:38402075-38431825 (+)
C3H/HeJ	MGP_C3HHeJ_G0024849	protein coding gene	Chr19:39756950-39789931 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025533	protein coding gene	Chr19:41365995-41398597 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022946	protein coding gene	Chr19:37714946-37744651 (+)
CAST/EiJ	MGP_CASTEiJ_G0024314	protein coding gene	Chr19:39393688-39422039 (+)
CBA/J	MGP_CBAJ_G0024829	protein coding gene	Chr19:43373736-43411165 (+)
DBA/2J	MGP_DBA2J_G0024961	protein coding gene	Chr19:38213177-38243209 (+)
FVB/NJ	MGP_FVBNJ_G0024922	protein coding gene	Chr19:37965595-37997932 (+)
LP/J	MGP_LPJ_G0025047	protein coding gene	Chr19:40304109-40335410 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024953	protein coding gene	Chr19:43038018-43069846 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025590	protein coding gene	Chr19:39640394-39674412 (+)
PWK/PhJ	MGP_PWKPhJ_G0024064	protein coding gene	Chr19:38062052-38091565 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023867	protein coding gene	Chr19:38385258-38414905 (+)
WSB/EiJ	MGP_WSBEiJ_G0024384	protein coding gene	Chr19:39808821-39839992 (+)

Human Ortholog

DNTT, DNA nucleotidylexotransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNTT, DNA nucleotidylexotransferase
Synonyms

TDT
Links

HGNC:2983

NCBI Gene ID: 1791

neXtProt AC: NX_P04053

UniProt: P04053
Chr Location

10q24.1; chr10:96304409-96338564 (+) GRCh38

MGI Vertebrate Homology

Dntt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNTT
Protein SuperFamily

DNA_NT
Gene Tree

Dntt

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Phenotype Summary

9 phenotypes from 4 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
35 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

5
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous inactivation of this gene results in lack of "N" nucleotide insertions at the junctions of immunoglobulin and T cell receptor V(D)J rearrangements. Forced expression of terminal deoxynucleotidyl transferase in fetal thymus leads to decreased gamma-delta T cell number.

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

738
Tissues

17
cDNA Data

24
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

8
UniProt

3
CCDS

CCDS29807.1, CCDS37984.1

Ensembl

ENSMUSG00000025014 (Evidence)
NCBI Gene

21673

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025014	Ensembl Gene Model \| MGI Sequence Detail	30251	C57BL/6J	± kb
transcript	ENSMUST00000051806	Ensembl \| MGI Sequence Detail	2130	Not Applicable
polypeptide	ENSMUSP00000062078	Ensembl \| MGI Sequence Detail	530	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006611 DNA nucleotidylexotransferase

(term hierarchy)
PDB

1JMS, 1KDH, 1KEJ, 4I27, 4I28, 4I29, 4I2A, 4I2B, 4I2C, 4I2D, 4I2E, 4I2F, 4I2G, 4I2H, 4I2I, 4I2J, 4IQT, 4IQU, 4IQV, 4IQW, 4QZ8, 4QZ9, 4QZA, 4QZB, 4QZC, 4QZD, 4QZE, 4QZF, 4QZG, 4QZH, 4QZI, 5D46, 5D49, 5D4B, 6GO3, 6GO4, 6GO5, 6GO6, 6GO7
EC

2.7.7.31, 3.1.11.-
InterPro Domains

IPR001357 BRCT domain

IPR036420 BRCT domain superfamily

IPR002054 DNA-directed DNA polymerase X

IPR027292 DNA nucleotidylexotransferase (TdT)

IPR001726 DNA nucleotidylexotransferase (TdT) / DNA-directed DNA/RNA polymerase mu

IPR010996 DNA polymerase beta-like, N-terminal domain

IPR029398 DNA polymerase beta, thumb domain

IPR022312 DNA polymerase family X

IPR019843 DNA polymerase family X, binding site

IPR018944 DNA polymerase lambda, fingers domain

IPR027421 DNA polymerase lambda lyase domain superfamily

IPR037160 DNA polymerase, thumb domain superfamily

IPR043519 Nucleotidyltransferase superfamily

IPR002934 Polymerase, nucleotidyl transferase domain

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All nucleic 38

Genomic 6

cDNA 27

Primer pair 3

Other 2

Microarray probesets 7

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MGD-MRK-14985, MGI:2147771

Summaries

All 98

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 35
Earliest

J:22043 Landau NR, et al., Cloning of terminal transferase cDNA by antibody screening. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5836-40
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dntt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156412	Chr19:41017818-41017837 (+)	114 bp
Tssr156413	Chr19:41033312-41033321 (+)	15,603 bp
Tssr156414	Chr19:41038846-41038860 (+)	21,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24