Tek MGI Mouse Gene Detail - MGI:98664 - TEK receptor tyrosine kinase

Symbol

Tek
Name

TEK receptor tyrosine kinase
Synonyms

Cd202b, Hyk, tie-2, Tie2

Feature Type

protein coding gene
IDs

MGI:98664
NCBI Gene: 21687
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr4:94627526-94763213 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 43.34 cM
Mapping Data

9 experiments

SNPs within 2kb

3182 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98664	protein coding gene	Chr4:94627322-94763213 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028453	protein coding gene	Chr4:94798622-94933122 (+)
A/J	MGP_AJ_G0028416	protein coding gene	Chr4:91484884-91610030 (+)
AKR/J	MGP_AKRJ_G0028363	protein coding gene	Chr4:93672288-93805602 (+)
BALB/cJ	MGP_BALBcJ_G0028434	protein coding gene	Chr4:91729773-91854402 (+)
C3H/HeJ	MGP_C3HHeJ_G0028147	protein coding gene	Chr4:94496221-94625842 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028873	protein coding gene	Chr4:98419832-98577085 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026167	protein coding gene	Chr4:87004734-87121360 (+)
CAST/EiJ	MGP_CASTEiJ_G0027587	protein coding gene	Chr4:92365880-92489186 (+)
CBA/J	MGP_CBAJ_G0028116	protein coding gene	Chr4:101436615-101575454 (+)
DBA/2J	MGP_DBA2J_G0028266	protein coding gene	Chr4:91262567-91396102 (+)
FVB/NJ	MGP_FVBNJ_G0028233	protein coding gene	Chr4:90130388-90257184 (+)
LP/J	MGP_LPJ_G0028366	protein coding gene	Chr4:95127008-95255371 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028261	protein coding gene	Chr4:107200658-107344059 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028911	protein coding gene	Chr4:93947202-94082647 (+)
PWK/PhJ	MGP_PWKPhJ_G0027312	protein coding gene	Chr4:89430351-89551619 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027133	protein coding gene	Chr4:91367582-91503156 (+)
WSB/EiJ	MGP_WSBEiJ_G0027665	protein coding gene	Chr4:94102292-94237739 (+)

Human Ortholog

TEK, TEK receptor tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEK, TEK receptor tyrosine kinase
Synonyms

CD202B, GLC3E, TIE-2, TIE2, VMCM, VMCM1
Links

HGNC:11724

NCBI Gene ID: 7010

neXtProt AC: NX_Q02763

UniProt: Q02763
Chr Location

9p21.2; chr9:27109141-27230178 (+) GRCh38

MGI Vertebrate Homology

Tek stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TEK
Protein SuperFamily

TyrPK_CSF1-R
Gene Tree

Tek

Diseases

3 with human TEK associations

				Human Disease	Mouse Models
				arteriovenous malformation IDs arteriovenous malformation DOID:11294 ICD10CM:I77.0 NCI:C2882 UMLS_CUI:C0334533
				multiple cutaneous and mucosal venous malformations IDs multiple cutaneous and mucosal venous malformations DOID:0050792 MESH:C563977 OMIM:600195 ORDO:2451 UMLS_CUI:C1838437
				renal Wilms' tumor IDs renal Wilms' tumor DOID:5176 NCI:C6951 UMLS_CUI:C1335062

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 5 alleles in 7 genetic backgrounds
30 phenotypes from multigenic genotypes
66 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

5
Radiation induced

1
Targeted

14
Genomic Mutations

3 involving Tek
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

92 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results in embryonic lethality during organogenesis, impaired vascular branching in the embryo and yolk sac, abnormal cardiac development, and in some cases hemorrhages.

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All GO Annotations

128
GO References

25

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1132
Tissues

217
cDNA Data

59
Literature Summary

203

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TEK

Xenbase tek

ZFIN tek

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All Sequences

47
RefSeq

8
UniProt

3
CCDS

CCDS18361.1, CCDS71421.1, CCDS80122.1

Ensembl

ENSMUSG00000006386 (Evidence)
NCBI Gene

21687

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006386	Ensembl Gene Model \| MGI Sequence Detail	135688	C57BL/6J	± kb
transcript	ENSMUST00000102798	Ensembl \| MGI Sequence Detail	4654	Not Applicable
polypeptide	ENSMUSP00000099862	Ensembl \| MGI Sequence Detail	1123	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000002032 angiopoietin-1 receptor

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR000742 EGF-like domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR002049 Laminin-type EGF domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
GlyGen

Q02858 9 sites, 4 N-linked glycans (4 sites)

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All nucleic 93

Genomic 3

cDNA 59

Primer pair 21

Other 10

Microarray probesets 3

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MGD-MRK-14991, MGD-MRK-16702, MGD-MRK-18601, MGI:2140157

Summaries

All 365

Developmental Gene Expression 203

Gene Ontology 25

Phenotypes 66
Earliest

J:1682 Dumont DJ, et al., tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors. Oncogene. 1992 Aug;7(8):1471-80
Latest

J:358456 Schwakopf J, et al., Schlemm's canal-selective Tie2/TEK knockdown induces sustained ocular hypertension in adult mice. Exp Eye Res. 2024 Nov;248:110114

TSS for Tek:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr37803	Chr4:94627513-94627535 (+)	-2 bp
Tssr37804	Chr4:94627685-94627692 (+)	163 bp
Tssr37805	Chr4:94627699-94627721 (+)	184 bp
Tssr37806	Chr4:94627730-94627750 (+)	214 bp
Tssr37807	Chr4:94627759-94627774 (+)	241 bp
Tssr37808	Chr4:94627802-94627824 (+)	287 bp
Tssr1232	Chr4:94628255-94628258 (+)	731 bp
Tssr37809	Chr4:94639820-94639823 (+)	12,296 bp
Tssr37810	Chr4:94709006-94709022 (+)	81,488 bp
Tssr37811	Chr4:94733985-94733989 (+)	106,461 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24