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Tgfa Gene Detail
Summary
  • Symbol
    Tgfa
  • Name
    transforming growth factor alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:98724
    NCBI Gene: 21802
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86172205-86252701 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.62 cM
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2047 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98724
 protein coding gene Chr6:86172020-86252726 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030971
 protein coding gene Chr6:87458767-87542306 (+)
A/J MGP_AJ_G0030937
 protein coding gene Chr6:84090047-84169891 (+)
AKR/J MGP_AKRJ_G0030868
 protein coding gene Chr6:86522176-86602273 (+)
BALB/cJ MGP_BALBcJ_G0030950
 protein coding gene Chr6:84093599-84174084 (+)
C3H/HeJ MGP_C3HHeJ_G0030760
 protein coding gene Chr6:97855904-97936259 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031407
 protein coding gene Chr6:89841547-89923005 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028591
 protein coding gene Chr6:82254129-82337391 (+)
CAST/EiJ MGP_CASTEiJ_G0030059
 protein coding gene Chr6:86590269-86674304 (+)
CBA/J MGP_CBAJ_G0030634
 protein coding gene Chr6:93369547-93456459 (+)
DBA/2J MGP_DBA2J_G0030790
 protein coding gene Chr6:83410012-83490936 (+)
FVB/NJ MGP_FVBNJ_G0030743
 protein coding gene Chr6:82591333-82671761 (+)
LP/J MGP_LPJ_G0030867
 protein coding gene Chr6:87502596-87583704 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030776
 protein coding gene Chr6:97518486-97600777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031434
 protein coding gene Chr6:86371418-86454176 (+)
PWK/PhJ MGP_PWKPhJ_G0029774
 protein coding gene Chr6:82348922-82431564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029602
 protein coding gene Chr6:85209956-85293544 (+)
WSB/EiJ MGP_WSBEiJ_G0030140
 protein coding gene Chr6:86817558-86902484 (+)



Homology
more
  • Human Ortholog
    TGFA, transforming growth factor alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGFA, transforming growth factor alpha
  • Synonyms
    TFGA
  • Links
    NCBI Gene ID: 7039
    neXtProt AC: NX_P01135
    UniProt: P01135

  • Chr Location
    2p13.3; chr2:70447284-70554193 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TGFA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants have curly vibrissae, wavy hair with misaligned hair follicles, reduced body weight, and eye defects including open eyelids at birth, corneal scarring and microphthalmia. Some heterozygotes show mild forms of the eye abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    45
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1054
  • Tissues
    118
  • cDNA Data
    206
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029999 Ensembl Gene Model | MGI Sequence Detail 80497 C57BL/6J ±  kb
    transcript ENSMUST00000032066 Ensembl | MGI Sequence Detail 4527 Not Applicable  
    polypeptide ENSMUSP00000032066 Ensembl | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 228
      Genomic 6
      cDNA 208
      Primer pair 11
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15062, MGD-MRK-15421, MGD-MRK-15423
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 57
      Gene Ontology 16
      Phenotypes 50
    • Earliest
      J:13034 Crew FAE, Waved: an autosomal recessive coat form character in the mouse. J Genet. 1933;27(1):95-96
    • Latest
      J:334122 Glover JD, et al., The developmental basis of fingerprint pattern formation and variation. Cell. 2023 Mar 2;186(5):940-956.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory