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Tgm2 Gene Detail
Summary
  • Symbol
    Tgm2
  • Name
    transglutaminase 2, C polypeptide
  • Synonyms
    G[a]h, protein-glutamine gamma-glutamyltransferase, TG2, TGase2, TG C, tissue transglutaminase, tTG, tTGas
  • Feature Type
    protein coding gene
  • IDs
    MGI:98731
    NCBI Gene: 21817
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:157958325-157988312 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1048 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98731
 protein coding gene Chr2:157958322-157988356 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026789
 protein coding gene Chr2:163172011-163201969 (-)
A/J MGP_AJ_G0026755
 protein coding gene Chr2:156635515-156665527 (-)
AKR/J MGP_AKRJ_G0026726
 protein coding gene Chr2:161255690-161285659 (-)
BALB/cJ MGP_BALBcJ_G0026764
 protein coding gene Chr2:156937272-156968339 (-)
C3H/HeJ MGP_C3HHeJ_G0026506
 protein coding gene Chr2:161563886-161595698 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027213
 protein coding gene Chr2:168028970-168058899 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024583
 protein coding gene Chr2:150079074-150109078 (-)
CAST/EiJ MGP_CASTEiJ_G0025968
 protein coding gene Chr2:161922787-161954250 (-)
CBA/J MGP_CBAJ_G0026483
 protein coding gene Chr2:174063194-174093518 (-)
DBA/2J MGP_DBA2J_G0026621
 protein coding gene Chr2:155808490-155838470 (-)
FVB/NJ MGP_FVBNJ_G0026588
 protein coding gene Chr2:154210050-154241301 (-)
LP/J MGP_LPJ_G0026724
 protein coding gene Chr2:163256514-163294135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026609
 protein coding gene Chr2:177875360-177905265 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027269
 protein coding gene Chr2:161068987-161099965 (-)
PWK/PhJ MGP_PWKPhJ_G0025702
 protein coding gene Chr2:155326810-155357213 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025505
 protein coding gene Chr2:159996035-160025853 (-)
WSB/EiJ MGP_WSBEiJ_G0026038
 protein coding gene Chr2:161970508-162001907 (-)



Homology
more
  • Human Ortholog
    TGM2, transglutaminase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGM2, transglutaminase 2
  • Synonyms
    G(h), hTG2, TG(C), TGC, tTG
  • Links
    NCBI Gene ID: 7052
    neXtProt AC: NX_P21980
    UniProt: P21980

  • Chr Location
    20q11.23; chr20:38127385-38168475 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tgm2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous null mutation causes alterations in glucose and aerobic energy metabolism, tumor growth, and response to myocardial infarction, liver injury, and LPS-induced sepsis. A second null mutation confers resistance to renal injury, while a third one alters cell adhesion and T cell physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1321
  • Tissues
    268
  • cDNA Data
    204
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21817 NCBI Gene Model | MGI Sequence Detail 29988 C57BL/6J ±  kb
    transcript NM_009373 RefSeq | MGI Sequence Detail 3549 ZRU/MplStud  
    polypeptide P21981 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 220
      Genomic 4
      cDNA 205
      Primer pair 10
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15073
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 24
      Diseases 3
      Gene Ontology 20
      Phenotypes 95
    • Earliest
      J:10915 Gentile V, et al., Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 5;266(1):478-83
    • Latest
      J:354037 Liu C, et al., Microglial transglutaminase 2 deficiency causes impaired synaptic remodelling and cognitive deficits in mice. Cell Prolif. 2023 Sep;56(9):e13439
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory