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Thbd Gene Detail
Summary
  • Symbol
    Thbd
  • Name
    thrombomodulin
  • Synonyms
    CD141, TM
  • Feature Type
    protein coding gene
  • IDs
    MGI:98736
    NCBI Gene: 21824
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:148246391-148250108 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 73.45 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98736
 protein coding gene Chr2:148246386-148250108 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026607
 protein coding gene Chr2:152746703-152750425 (-)
A/J MGP_AJ_G0026571
 protein coding gene Chr2:146536461-146540179 (-)
AKR/J MGP_AKRJ_G0026545
 protein coding gene Chr2:150768768-150772490 (-)
BALB/cJ MGP_BALBcJ_G0026583
 protein coding gene Chr2:146956135-146959857 (-)
C3H/HeJ MGP_C3HHeJ_G0026326
 protein coding gene Chr2:151267635-151271357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027028
 protein coding gene Chr2:157191956-157195678 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024406
 protein coding gene Chr2:140544197-140547939 (-)
CAST/EiJ MGP_CASTEiJ_G0025787
 protein coding gene Chr2:151655169-151658888 (-)
CBA/J MGP_CBAJ_G0026306
 protein coding gene Chr2:162958434-162962156 (-)
DBA/2J MGP_DBA2J_G0026440
 protein coding gene Chr2:145806034-145809752 (-)
FVB/NJ MGP_FVBNJ_G0026404
 protein coding gene Chr2:144302448-144306172 (-)
LP/J MGP_LPJ_G0026544
 protein coding gene Chr2:152863834-152867556 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026424
 protein coding gene Chr2:167030268-167033986 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027083
 protein coding gene Chr2:150774169-150777887 (-)
PWK/PhJ MGP_PWKPhJ_G0025523
 protein coding gene Chr2:145488682-145492400 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025324
 protein coding gene Chr2:149743757-149747483 (-)
WSB/EiJ MGP_WSBEiJ_G0025861
 protein coding gene Chr2:151728721-151732443 (-)



Homology
more
  • Human Ortholog
    THBD, thrombomodulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THBD, thrombomodulin
  • Synonyms
    AHUS6, BDCA-3, BDCA3, CD141, THPH12, THRM, TM
  • Links
    NCBI Gene ID: 7056
    neXtProt AC: NX_P07204
    UniProt: P07204

  • Chr Location
    20p11.21; chr20:23045633-23049672 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Thbd mouse models; 9 with human THBD associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 11 alleles in 15 genetic backgrounds
    11 phenotypes from multigenic genotypes
    3 images
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted null mutants are growth retarded and die by embryonic day 9.5. Embryos develop further in vitro than in vivo suggesting maternal-fetal incompatibility. Endothelial cell-specific, conditional knockouts suffer fatal juvenile thromboses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1447
  • Tissues
    204
  • cDNA Data
    46
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21824 NCBI Gene Model | MGI Sequence Detail 3718 C57BL/6J ±  kb
    transcript NM_009378 RefSeq | MGI Sequence Detail 3718 Not Specified  
    polypeptide P15306 UniProt | EBI | MGI Sequence Detail 577 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 10
      cDNA 48
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15081, MGI:2138918
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 25
      Diseases 1
      Gene Ontology 7
      Phenotypes 59
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory