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Thra Gene Detail
Summary
  • Symbol
    Thra
  • Name
    thyroid hormone receptor alpha
  • Synonyms
    6430529J03Rik, c-erbAalpha, Erba, Nr1a1, Rvr, T3R[a], T3Ralpha, Thra1, Thra2, TR alpha 1, TR alpha 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98742
    NCBI Gene: 21833
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98631539-98659832 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.58 cM, cytoband D-E
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98742
 protein coding gene Chr11:98631464-98659832 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019071
 protein coding gene Chr11:101340817-101370520 (+)
A/J MGP_AJ_G0019039
 protein coding gene Chr11:97097295-97125601 (+)
AKR/J MGP_AKRJ_G0019009
 protein coding gene Chr11:100106000-100134350 (+)
BALB/cJ MGP_BALBcJ_G0019013
 protein coding gene Chr11:97592781-97621576 (+)
C3H/HeJ MGP_C3HHeJ_G0018826
 protein coding gene Chr11:100248746-100277463 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019464
 protein coding gene Chr11:104436652-104473840 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017096
 protein coding gene Chr11:94656220-94684544 (+)
CAST/EiJ MGP_CASTEiJ_G0018380
 protein coding gene Chr11:101232236-101265988 (+)
CBA/J MGP_CBAJ_G0018797
 protein coding gene Chr11:108791302-108821402 (+)
DBA/2J MGP_DBA2J_G0018905
 protein coding gene Chr11:96655395-96684239 (+)
FVB/NJ MGP_FVBNJ_G0018894
 protein coding gene Chr11:96168436-96199514 (+)
LP/J MGP_LPJ_G0018975
 protein coding gene Chr11:101796858-101825918 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018921
 protein coding gene Chr11:108508983-108539134 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019504
 protein coding gene Chr11:100455076-100485321 (+)
PWK/PhJ MGP_PWKPhJ_G0018151
 protein coding gene Chr11:97695415-97725405 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017940
 protein coding gene Chr11:100194687-100223097 (+)
WSB/EiJ MGP_WSBEiJ_G0018429
 protein coding gene Chr11:100403676-100436241 (+)



Homology
more
  • Human Ortholog
    THRA, thyroid hormone receptor alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THRA, thyroid hormone receptor alpha
  • Synonyms
    AR7, c-erbA, c-ERBA-1, CHNG6, EAR7, ERBA, ERBA1, ERB-T-1, NR1A1, THRA1, THRA2, THRalpha, THRalpha1, THRalpha2, TRalpha, TRalpha1, TRalpha2
  • Links
    NCBI Gene ID: 7067
    neXtProt AC: NX_P10827
    UniProt: P10827

  • Chr Location
    17q21.1; chr17:40058290-40093867 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Thra mouse models; 2 with human THRA associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    132 phenotypes from 17 alleles in 19 genetic backgrounds
    90 phenotypes from multigenic genotypes
    174 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in diverse phenotypes depending on the location and severity of the mutation. Observed phenotypes may include alterations in thyroid physiology, intestinal remodeling, cerebellum development, bone growth, cardiac function, thermogenesis, and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    970
  • Tissues
    218
  • cDNA Data
    27
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21833 NCBI Gene Model | MGI Sequence Detail 28294 C57BL/6J ±  kb
    transcript NM_001313983 RefSeq | MGI Sequence Detail 2491 ZRU/MplStud  
    polypeptide P63058 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 3
      cDNA 31
      Primer pair 7
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15091, MGD-MRK-15092, MGD-MRK-15093, MGD-MRK-19597, MGD-MRK-9569, MGI:2144519, MGI:2441716
    References
    more
    • Summaries
      All 323
      Developmental Gene Expression 36
      Diseases 1
      Gene Ontology 30
      Phenotypes 174
    • Earliest
      J:5152 Pizarro O, et al., A study of recombination between the H-2 (histocompatibility) locus and loci closely linked with it in the house mouse. Transplantation. 1970 Mar;9(3):207-18
    • Latest
      J:353819 Wenzek C, et al., Lack of canonical thyroid hormone receptor alpha signaling changes regulatory T cell phenotype in female mice. iScience. 2024 Aug 16;27(8):110547
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory