Thy1 MGI Mouse Gene Detail - MGI:98747 - thymus cell antigen 1, theta

Symbol

Thy1
Name

thymus cell antigen 1, theta
Synonyms

CD90, T25, theta, Thy-1, Thy1.1, Thy 1.2, Thy-1.2, Thy1.2

Feature Type

protein coding gene
IDs

MGI:98747
NCBI Gene: 21838
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr9:43954681-43959876 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.52 cM
Mapping Data

55 experiments

SNPs within 2kb

250 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98747	protein coding gene	Chr9:43954681-43959876 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034688	protein coding gene	Chr9:42488490-42493710 (+)
A/J	MGP_AJ_G0034668	protein coding gene	Chr9:41327259-41332429 (+)
AKR/J	MGP_AKRJ_G0034594	protein coding gene	Chr9:42180842-42188120 (+)
BALB/cJ	MGP_BALBcJ_G0034659	protein coding gene	Chr9:41067582-41073086 (+)
C3H/HeJ	MGP_C3HHeJ_G0034370	protein coding gene	Chr9:42630677-42637106 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035182	protein coding gene	Chr9:43769626-43774846 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032095	protein coding gene	Chr9:40920401-40925482 (+)
CAST/EiJ	MGP_CASTEiJ_G0033693	protein coding gene	Chr9:42473493-42479163 (+)
CBA/J	MGP_CBAJ_G0034343	protein coding gene	Chr9:45340464-45348291 (+)
DBA/2J	MGP_DBA2J_G0034502	protein coding gene	Chr9:41241109-41246299 (+)
FVB/NJ	MGP_FVBNJ_G0034442	protein coding gene	Chr9:40487798-40492867 (+)
LP/J	MGP_LPJ_G0034583	protein coding gene	Chr9:42795417-42801147 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034486	protein coding gene	Chr9:47221962-47228095 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035201	protein coding gene	Chr9:42077784-42083960 (+)
PWK/PhJ	MGP_PWKPhJ_G0033398	protein coding gene	Chr9:41104087-41109868 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033234	protein coding gene	Chr9:42379469-42384690 (+)
WSB/EiJ	MGP_WSBEiJ_G0033806	protein coding gene	Chr9:42115743-42120975 (+)

Human Ortholog

THY1, Thy-1 cell surface antigen

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THY1, Thy-1 cell surface antigen
Synonyms

CD90, CDw90
Links

HGNC:11801

NCBI Gene ID: 7070

neXtProt AC: NX_P04216

UniProt: P04216
Chr Location

11q23.3; chr11:119415476-119424985 (-) GRCh38

MGI Vertebrate Homology

Thy1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THY1
Gene Tree

Thy1

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Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
31 phenotypes from multigenic genotypes
152 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

8
Gene trapped

1
Targeted

6
Transgenic

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

211 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice are viable, fertile, and display no abnormalities in the brain and spinal cord, have normal axonal development and regeneration and no behavioral abnormalities. Long term potentiation is inhibited in the dentate gyrus.

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All GO Annotations

80
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

945
Tissues

75
cDNA Data

56
Literature Summary

50

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thy1

ZFIN thy1

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All Sequences

54
RefSeq

2
UniProt

5
CCDS

CCDS23093.1

Ensembl

ENSMUSG00000032011 (Evidence)
NCBI Gene

21838

			Length	Strain/Species	Flank
genomic	21838	NCBI Gene Model \| MGI Sequence Detail	5196	C57BL/6J	± kb
transcript	NM_009382	RefSeq \| MGI Sequence Detail	1753	C57BL/6
polypeptide	P01831	UniProt \| EBI \| MGI Sequence Detail	162	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001843 Thy-1 membrane glycoprotein

(term hierarchy)
InterPro Domains

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR013106 Immunoglobulin V-set domain

IPR033292 Thy-1 membrane glycoprotein
GlyGen

P01831 4 sites, 45 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 85

Genomic 18

cDNA 59

Primer pair 7

Other 1

Microarray probesets 2

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MGD-MRK-15100, MGD-MRK-15102

Summaries

All 329

Developmental Gene Expression 50

Diseases 2

Gene Ontology 19

Phenotypes 152
Earliest

J:24839 REIF AE, et al., THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413-33
Latest

J:358144 Messmer JM, et al., T lymphocyte recruitment to melanoma brain tumors depends on distinct venous vessels. Immunity. 2024 Nov 12;57(11):2688-2703.e11

TSS for Thy1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84582	Chr9:43954508-43954550 (+)	-152 bp
Tssr84583	Chr9:43954564-43954577 (+)	-110 bp
Tssr84584	Chr9:43954687-43954731 (+)	28 bp
Tssr84585	Chr9:43957071-43957084 (+)	2,397 bp
Tssr84586	Chr9:43957241-43957253 (+)	2,566 bp
Tssr84587	Chr9:43957903-43957914 (+)	3,228 bp
Tssr84588	Chr9:43957924-43957950 (+)	3,256 bp
Tssr84589	Chr9:43958085-43958115 (+)	3,419 bp
Tssr84590	Chr9:43958135-43958146 (+)	3,460 bp
Tssr84591	Chr9:43958167-43958181 (+)	3,493 bp
Tssr84592	Chr9:43958201-43958213 (+)	3,526 bp
Tssr84593	Chr9:43958687-43958719 (+)	4,022 bp
Tssr84594	Chr9:43958781-43958793 (+)	4,106 bp
Tssr84595	Chr9:43958869-43958880 (+)	4,194 bp
Tssr84596	Chr9:43958899-43958947 (+)	4,242 bp
Tssr84597	Chr9:43959216-43959232 (+)	4,543 bp
Tssr84598	Chr9:43959268-43959282 (+)	4,594 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24