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Tjp1 Gene Detail
Summary
  • Symbol
    Tjp1
  • Name
    tight junction protein 1
  • Synonyms
    ZO-1, ZO1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98759
    NCBI Gene: 21872
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:64945913-65177529 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 35.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5948 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98759
 protein coding gene Chr7:64945913-65177629 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032342
 protein coding gene Chr7:66463804-66714849 (-)
A/J MGP_AJ_G0032321
 protein coding gene Chr7:65122277-65367957 (-)
AKR/J MGP_AKRJ_G0032257
 protein coding gene Chr7:66510037-66762491 (-)
BALB/cJ MGP_BALBcJ_G0032333
 protein coding gene Chr7:64861937-65099648 (-)
C3H/HeJ MGP_C3HHeJ_G0032046
 protein coding gene Chr7:67176448-67425208 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032826
 protein coding gene Chr7:69342523-69605106 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029833
 protein coding gene Chr7:68042867-68276034 (-)
CAST/EiJ MGP_CASTEiJ_G0031375
 protein coding gene Chr7:57821411-58061051 (-)
CBA/J MGP_CBAJ_G0032012
 protein coding gene Chr7:71505680-71770576 (-)
DBA/2J MGP_DBA2J_G0032168
 protein coding gene Chr7:63850491-64086452 (-)
FVB/NJ MGP_FVBNJ_G0032122
 protein coding gene Chr7:63976309-64210139 (-)
LP/J MGP_LPJ_G0032248
 protein coding gene Chr7:67705328-67956955 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032159
 protein coding gene Chr7:71784352-72049024 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032843
 protein coding gene Chr7:65852040-66099891 (-)
PWK/PhJ MGP_PWKPhJ_G0031095
 protein coding gene Chr7:56887691-57121842 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030936
 protein coding gene Chr7:52905218-53141608 (-)
WSB/EiJ MGP_WSBEiJ_G0031493
 protein coding gene Chr7:66203109-66436113 (-)



Homology
more
  • Human Ortholog
    TJP1, tight junction protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TJP1, tight junction protein 1
  • Synonyms
    ZO-1
  • Links
    NCBI Gene ID: 7082
    neXtProt AC: NX_Q07157
    UniProt: Q07157

  • Chr Location
    15q13.1; chr15:29699367-29969049 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    38 phenotypes from 3 alleles in 5 genetic backgrounds
    18 phenotypes from multigenic genotypes
    4 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show embryonic lethality and growth retardation, failure of embryo turning and chorioallantoic fusion, defective yolk sac angiogenesis, and increased apoptosis in the notochord, neural tube, somite and allantois. Homozygotes for a reporter allele are overtly normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    96
  • GO References
    81
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1453
  • Tissues
    284
  • cDNA Data
    151
  • Literature Summary
    493
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030516 Ensembl Gene Model | MGI Sequence Detail 231617 C57BL/6J ±  kb
    transcript ENSMUST00000102592 Ensembl | MGI Sequence Detail 7049 Not Applicable  
    polypeptide ENSMUSP00000099652 Ensembl | MGI Sequence Detail 1745 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 164
      cDNA 152
      Primer pair 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15119
    References
    more
    • Summaries
      All 642
      Developmental Gene Expression 493
      Diseases 1
      Gene Ontology 81
      Phenotypes 39
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:359192 Siegerist F, et al., The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights. iScience. 2024 Dec 20;27(12):111329
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory