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Tk1 Gene Detail
Summary
  • Symbol
    Tk1
  • Name
    thymidine kinase 1
  • Synonyms
    D530002A18Rik, Tk-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98763
    NCBI Gene: 21877
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:117706352-117716918 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 82.96 cM, cytoband E1-E2
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98763
 protein coding gene Chr11:117706345-117716918 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019454
 protein coding gene Chr11:122097554-122108333 (-)
A/J MGP_AJ_G0019422
 protein coding gene Chr11:116686549-116698122 (-)
AKR/J MGP_AKRJ_G0019392
 protein coding gene Chr11:120238893-120251309 (-)
BALB/cJ MGP_BALBcJ_G0019397
 protein coding gene Chr11:117058441-117069287 (-)
C3H/HeJ MGP_C3HHeJ_G0019203
 protein coding gene Chr11:120520497-120533635 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019846
 protein coding gene Chr11:125823736-125834111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017471
 protein coding gene Chr11:113695401-113705658 (-)
CAST/EiJ MGP_CASTEiJ_G0018757
 protein coding gene Chr11:121949306-121959712 (-)
CBA/J MGP_CBAJ_G0019174
 protein coding gene Chr11:130777937-130788855 (-)
DBA/2J MGP_DBA2J_G0019286
 protein coding gene Chr11:116087628-116098920 (-)
FVB/NJ MGP_FVBNJ_G0019278
 protein coding gene Chr11:115707352-115717852 (-)
LP/J MGP_LPJ_G0019356
 protein coding gene Chr11:122422174-122433171 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019311
 protein coding gene Chr11:129738146-129749320 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019885
 protein coding gene Chr11:120888152-120900896 (-)
PWK/PhJ MGP_PWKPhJ_G0018523
 protein coding gene Chr11:117443397-117454198 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018315
 protein coding gene Chr11:120619543-120629857 (-)
WSB/EiJ MGP_WSBEiJ_G0018809
 protein coding gene Chr11:120855104-120866674 (-)



Homology
more
  • Human Ortholog
    TK1, thymidine kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TK1, thymidine kinase 1
  • Synonyms
    TK2
  • Links
    NCBI Gene ID: 7083
    neXtProt AC: NX_P04183
    UniProt: P04183

  • Chr Location
    17q25.3; chr17:78174079-78187233 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show partial postnatal lethality, poor fertility, hemosiderosis, lymphocyte and spleen anomalies, altered sublingual gland secretion, inflammation of the arteries, lung, liver and thyroid, abnormal spermatogenesis and glomerulosclerosis leading to kidney failure and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    818
  • Tissues
    106
  • cDNA Data
    100
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025574 Ensembl Gene Model | MGI Sequence Detail 10567 C57BL/6J ±  kb
    transcript ENSMUST00000026661 Ensembl | MGI Sequence Detail 1440 Not Applicable  
    polypeptide ENSMUSP00000026661 Ensembl | MGI Sequence Detail 233 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      Genomic 5
      cDNA 100
      Primer pair 1
      Other 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15121, MGD-MRK-15124, MGI:2444019
    References
    more
    • Summaries
      All 90
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:5857 McBreen P, et al., Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11. Cytogenet Cell Genet. 1977;19(1):7-13
    • Latest
      J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory