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Tph1 Gene Detail
Summary
  • Symbol
    Tph1
  • Name
    tryptophan hydroxylase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98796
    NCBI Gene: 21990
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:46294065-46321961 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 30.43 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    949 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98796
 protein coding gene Chr7:46294065-46321961 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032266
 protein coding gene Chr7:47031199-47057247 (-)
A/J MGP_AJ_G0032245
 protein coding gene Chr7:46054287-46080292 (-)
AKR/J MGP_AKRJ_G0032181
 protein coding gene Chr7:47355937-47380840 (-)
BALB/cJ MGP_BALBcJ_G0032257
 protein coding gene Chr7:46063861-46089708 (-)
C3H/HeJ MGP_C3HHeJ_G0031972
 protein coding gene Chr7:47850569-47876927 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032749
 protein coding gene Chr7:49299956-49326727 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029763
 protein coding gene Chr7:48611598-48636952 (-)
CAST/EiJ MGP_CASTEiJ_G0031300
 protein coding gene Chr7:39294985-39321612 (-)
CBA/J MGP_CBAJ_G0031937
 protein coding gene Chr7:50947321-50975119 (-)
DBA/2J MGP_DBA2J_G0032094
 protein coding gene Chr7:45748499-45773767 (-)
FVB/NJ MGP_FVBNJ_G0032046
 protein coding gene Chr7:45542997-45568247 (-)
LP/J MGP_LPJ_G0032173
 protein coding gene Chr7:47723787-47748757 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032083
 protein coding gene Chr7:49568176-49593336 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032764
 protein coding gene Chr7:46572131-46597340 (-)
PWK/PhJ MGP_PWKPhJ_G0031023
 protein coding gene Chr7:39123331-39148695 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030861
 protein coding gene Chr7:34587231-34615498 (-)
WSB/EiJ MGP_WSBEiJ_G0031418
 protein coding gene Chr7:47075825-47103102 (-)



Homology
more
  • Human Ortholog
    TPH1, tryptophan hydroxylase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPH1, tryptophan hydroxylase 1
  • Synonyms
    TPRH, TRPH
  • Links
    NCBI Gene ID: 7166
    neXtProt AC: NX_P17752
    UniProt: P17752

  • Chr Location
    11p15.1; chr11:18017555-18046269 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with human TPH1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 5 alleles in 6 genetic backgrounds
    9 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display no gross behavioral abnormalities. Mice homozygous for a second null allele display fatigue, breathing difficulties, progressive pallor, and impaired cardiac function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    84
  • cDNA Data
    12
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21990 NCBI Gene Model | MGI Sequence Detail 27897 C57BL/6J ±  kb
    transcript NM_009414 RefSeq | MGI Sequence Detail 4581 ZRU/MplStud  
    polypeptide P17532 UniProt | EBI | MGI Sequence Detail 447 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 13
      cDNA 15
      Primer pair 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15178
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 36
      Gene Ontology 11
      Phenotypes 89
    • Earliest
      J:4454 Kulikov AV, et al., [Genetic control of tryptophan hydroxylase activity in the mouse brain]. Genetika. 1983 May;19(5):784-8
    • Latest
      J:351135 Field SL, et al., Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation. PLoS One. 2024;19(6):e0304910
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory