Psmd3 MGI Mouse Gene Detail - MGI:98858 - proteasome (prosome, macropain) 26S subunit, non-ATPase, 3

Symbol

Psmd3
Name

proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Synonyms

AntP91a, Psd3, Tstap91a

Feature Type

protein coding gene
IDs

MGI:98858
NCBI Gene: 22123
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:98573380-98586804 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.39 cM
Mapping Data

9 experiments

SNPs within 2kb

494 from dbSNP Build 142
Strain Annotations

18
PCR

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98858	protein coding gene	Chr11:98573380-98586805 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019068	protein coding gene	Chr11:101274348-101288536 (+)
A/J	MGP_AJ_G0019036	protein coding gene	Chr11:97038411-97051576 (+)
AKR/J	MGP_AKRJ_G0019006	protein coding gene	Chr11:100046786-100061608 (+)
BALB/cJ	MGP_BALBcJ_G0019010	protein coding gene	Chr11:97533566-97546521 (+)
C3H/HeJ	MGP_C3HHeJ_G0018823	protein coding gene	Chr11:100188531-100201497 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019461	protein coding gene	Chr11:104360253-104373418 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017093	protein coding gene	Chr11:94595278-94609055 (+)
CAST/EiJ	MGP_CASTEiJ_G0018377	protein coding gene	Chr11:101172283-101185161 (+)
CBA/J	MGP_CBAJ_G0018794	protein coding gene	Chr11:108726716-108740182 (+)
DBA/2J	MGP_DBA2J_G0018902	protein coding gene	Chr11:96597744-96610881 (+)
FVB/NJ	MGP_FVBNJ_G0018891	protein coding gene	Chr11:96105077-96120548 (+)
LP/J	MGP_LPJ_G0018972	protein coding gene	Chr11:101735388-101748330 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018918	protein coding gene	Chr11:108440452-108459193 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019501	protein coding gene	Chr11:100388892-100403350 (+)
PWK/PhJ	MGP_PWKPhJ_G0018148	protein coding gene	Chr11:97629126-97642993 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017937	protein coding gene	Chr11:100134296-100147719 (+)
WSB/EiJ	MGP_WSBEiJ_G0018426	protein coding gene	Chr11:100340892-100355285 (+)

Human Ortholog

PSMD3, proteasome 26S subunit, non-ATPase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PSMD3, proteasome 26S subunit, non-ATPase 3
Synonyms

P58, RPN3, S3, TSTA2
Links

HGNC:9560

NCBI Gene ID: 5709

neXtProt AC: NX_O43242

UniProt: O43242
Chr Location

17q21.1; chr17:39980807-39997959 (+) GRCh38

MGI Vertebrate Homology

Psmd3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PSMD3
Gene Tree

Psmd3

less

Phenotype Summary

13 phenotype references

All Mutations and Alleles

16
Gene trapped

11
Targeted

5
Genomic Mutations

1 involving Psmd3
Incidental Mutations

APF
Find Mice (IMSR)

30 strains or lines available

less

All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

267
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase psmd3

ZFIN psmd3

less

All Sequences

66
RefSeq

2
UniProt

5
CCDS

CCDS25359.1

Ensembl

ENSMUSG00000017221 (Evidence)
NCBI Gene

22123

			Length	Strain/Species	Flank
genomic	22123	NCBI Gene Model \| MGI Sequence Detail	13425	C57BL/6J	± kb
transcript	NM_009439	RefSeq \| MGI Sequence Detail	2167	FVB/N
polypeptide	P14685	UniProt \| EBI \| MGI Sequence Detail	530	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000013387 26S proteasome non-ATPase regulatory subunit 3

(term hierarchy)
InterPro Domains

IPR013586 26S proteasome regulatory subunit, C-terminal

IPR050756 COP9 signalosome complex subunit 3

IPR000717 Proteasome component (PCI) domain

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily
GlyGen

P14685 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

less

All nucleic 276

Genomic 4

cDNA 269

Primer pair 3

Microarray probesets 3

less

MGD-MRK-15286, MGD-MRK-34053, MGI:2144092

Summaries

All 53

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 13
Earliest

J:52726 Uyttenhove C, et al., Immunogenic variants obtained by mutagenesis of mouse mastocytoma P815. I. Rejection by syngeneic mice. J Exp Med. 1980 Nov 1;152(5):1175-83
Latest

J:236006 Hjerpe R, et al., UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome. Cell. 2016 Aug 11;166(4):935-49

TSS for Psmd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104760	Chr11:98573384-98573399 (+)	12 bp
Tssr104761	Chr11:98573404-98573438 (+)	41 bp
Tssr104762	Chr11:98573439-98573450 (+)	65 bp
Tssr104763	Chr11:98573614-98573644 (+)	249 bp
Tssr104764	Chr11:98576335-98576349 (+)	2,962 bp
Tssr104765	Chr11:98576718-98576727 (+)	3,343 bp
Tssr104766	Chr11:98576731-98576740 (+)	3,356 bp
Tssr104767	Chr11:98576742-98576752 (+)	3,367 bp
Tssr104768	Chr11:98576830-98576844 (+)	3,457 bp
Tssr104769	Chr11:98581350-98581364 (+)	7,977 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24