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Tuba1a Gene Detail
Summary
  • Symbol
    Tuba1a
  • Name
    tubulin, alpha 1A
  • Synonyms
    Talpha1 alpha-tubulin, Tuba-1, Tuba1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98869
    NCBI Gene: 22142
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98847728-98851382 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 55.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98869
 protein coding gene Chr15:98847718-98851584 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019721
 protein coding gene Chr12:49908443-49914837 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0022251
 protein coding gene Chr15:99718570-99729424 (-)
BALB/cJ MGP_BALBcJ_G0023076
 protein coding gene Chr17:2152854-2153607 (-)
C3H/HeJ MGP_C3HHeJ_G0022836
 protein coding gene Chr17:2259045-2259798 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0020253
 protein coding gene Chr15:92659383-92663143 (-)
CAST/EiJ MGP_CASTEiJ_G0022354
 protein coding gene Chr17:2274902-2275651 (-)
CBA/J MGP_CBAJ_G0022803
 protein coding gene Chr17:2445007-2445760 (-)
DBA/2J MGP_DBA2J_G0022938
 protein coding gene Chr17:2044194-2044947 (-)
FVB/NJ MGP_FVBNJ_G0034884
 protein coding gene Chr9:87414098-87415663 (+)
LP/J MGP_LPJ_G0019621
 protein coding gene Chr12:49932287-49938301 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022146
 protein coding gene Chr15:112008639-112012399 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023540
 protein coding gene Chr17:2254116-2257914 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0018577
 protein coding gene Chr12:43700156-43703500 (-)
WSB/EiJ MGP_WSBEiJ_G0021624
 protein coding gene Chr15:100332438-100335973 (-)



Homology
more
  • Human Ortholog
    TUBA1A, tubulin alpha 1a
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TUBA1A, tubulin alpha 1a
  • Synonyms
    B-ALPHA-1, LIS3, TUBA3
  • Links
    NCBI Gene ID: 7846
    neXtProt AC: NX_Q71U36
    UniProt: Q71U36

  • Chr Location
    12q13.12; chr12:49184686-49189324 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Tuba1a mouse models; 4 with human TUBA1A associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 3 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 6 alleles in 5 genetic backgrounds
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous mutation of this gene results in hyperactivity, reduced anxiety, impaired spatial working memory, and abnormalities in the laminar architecture of the hippocampus and cortex, accompanied by impaired neuronal migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    79
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    56
  • cDNA Data
    909
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22142 NCBI Gene Model | MGI Sequence Detail 3655 C57BL/6J ±  kb
    transcript NM_011653 RefSeq | MGI Sequence Detail 1591 ZRU/MplStud  
    polypeptide P68369 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 917
      cDNA 912
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15300, MGD-MRK-15301
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 21
      Diseases 3
      Gene Ontology 24
      Phenotypes 38
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:354846 Xiong H, et al., SALL2 regulates neural differentiation of mouse embryonic stem cells through Tuba1a. Cell Death Dis. 2024 Sep 30;15(9):710
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory