Txn1 MGI Mouse Gene Detail - MGI:98874

Symbol

Txn1
Name

thioredoxin 1
Synonyms

Trx1

Feature Type

protein coding gene
IDs

MGI:98874
NCBI Gene: 22166
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:57943373-57956411 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 31.87 cM
Mapping Data

6 experiments

SNPs within 2kb

455 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98874	protein coding gene	Chr4:57943373-57956411 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028321	protein coding gene	Chr4:56755409-56768407 (-)
A/J	MGP_AJ_G0028282	protein coding gene	Chr4:54603405-54616407 (-)
AKR/J	MGP_AKRJ_G0028231	protein coding gene	Chr4:56114806-56127829 (-)
BALB/cJ	MGP_BALBcJ_G0028301	protein coding gene	Chr4:54763673-54776677 (-)
C3H/HeJ	MGP_C3HHeJ_G0028022	protein coding gene	Chr4:56615378-56628382 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028742	protein coding gene	Chr4:58788728-58801711 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026048	protein coding gene	Chr4:51378266-51391339 (-)
CAST/EiJ	MGP_CASTEiJ_G0027460	protein coding gene	Chr4:56352595-56366710 (-)
CBA/J	MGP_CBAJ_G0027987	protein coding gene	Chr4:60775077-60788071 (-)
DBA/2J	MGP_DBA2J_G0028137	protein coding gene	Chr4:54501771-54514740 (-)
FVB/NJ	MGP_FVBNJ_G0028104	protein coding gene	Chr4:53726195-53739183 (-)
LP/J	MGP_LPJ_G0028236	protein coding gene	Chr4:56869395-56882391 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028128	protein coding gene	Chr4:63910989-63923995 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028778	protein coding gene	Chr4:56311387-56324365 (-)
PWK/PhJ	MGP_PWKPhJ_G0027185	protein coding gene	Chr4:54504142-54517866 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027013	protein coding gene	Chr4:55587630-55602078 (-)
WSB/EiJ	MGP_WSBEiJ_G0027538	protein coding gene	Chr4:56264209-56277213 (-)

Human Ortholog

TXN, thioredoxin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TXN, thioredoxin
Synonyms

TRDX, TRX, TRX1, Trx80, TXN1
Links

HGNC:12435

NCBI Gene ID: 7295

neXtProt AC: NX_P10599

UniProt: P10599
Chr Location

9q31.3; chr9:110243810-110256507 (-) GRCh38

MGI Vertebrate Homology

Txn1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TXN
Protein SuperFamily

Thioredoxin
Gene Tree

Txn1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

9
Targeted

4
Find Mice (IMSR)

15 strains or lines available

Homozygotes for a targeted null mutation die soon after implantation. In vitro, mutant embryos do not hatch, inner cell mass cells fail to proliferate, and trophoblasts do not attach to the feeder layer.

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All GO Annotations

40
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

16
cDNA Data

179
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase txn

ZFIN txna, txnb

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All Sequences

34
RefSeq

2
UniProt

1
CCDS

CCDS18207.1

Ensembl

ENSMUSG00000028367 (Evidence)
NCBI Gene

22166

			Length	Strain/Species	Flank
genomic	22166	NCBI Gene Model \| MGI Sequence Detail	13039	C57BL/6J	± kb
transcript	NM_011660	RefSeq \| MGI Sequence Detail	1051	ZRU/MplStud
polypeptide	P10639	UniProt \| EBI \| MGI Sequence Detail	105	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016853 thioredoxin

(term hierarchy)
InterPro Domains

IPR005746 Thioredoxin

IPR017937 Thioredoxin, conserved site

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily
GlyGen

P10639 1 site, 1 O-linked glycan (1 site)

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All nucleic 186

Genomic 5

cDNA 180

Primer pair 1

Microarray probesets 4

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MGD-MRK-15309, MGI:2140594

Summaries

All 95

Developmental Gene Expression 10

Gene Ontology 9

Phenotypes 12
Earliest

J:38106 Tagaya Y, et al., ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction [published erratum appears in EMBO J 1994 May 1;13(9):2244]. EMBO J. 1989 Mar;8(3):757-64
Latest

J:341367 Wu A, et al., Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with STAT3. Theranostics. 2023;13(14):4730-4744

TSS for Txn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1184	Chr4:57956416-57956424 (-)	-9 bp
Tssr1183	Chr4:57956311-57956358 (-)	76 bp
Tssr41866	Chr4:57956283-57956298 (-)	120 bp
Tssr41865	Chr4:57953520-57953533 (-)	2,884 bp
Tssr41864	Chr4:57951861-57951894 (-)	4,533 bp
Tssr41863	Chr4:57951842-57951860 (-)	4,560 bp
Tssr41862	Chr4:57943805-57943829 (-)	12,594 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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