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Zrsr2-ps1 Pseudogene Detail
Summary
  • Symbol
    Zrsr2-ps1
  • Name
    zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2, pseudogene 1
  • Synonyms
    35kDa, D11Ncvs75, Irlgs2, SP2, U2af1-rs1, U2afbp-rs, Zrsr1
  • Feature Type
    pseudogene
  • IDs
    MGI:98885
    NCBI Gene: 22183
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:22923228-22924514 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 14.24 cM, cytoband A3-4
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    84 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98885
 pseudogene Chr11:22922019-22926500 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018082
 protein coding gene Chr11:20684308-20687589 (+)
A/J MGP_AJ_G0018055
 protein coding gene Chr11:19898315-19901596 (+)
AKR/J MGP_AKRJ_G0018019
 protein coding gene Chr11:20609068-20612357 (+)
BALB/cJ MGP_BALBcJ_G0018023
 protein coding gene Chr11:20033694-20036977 (+)
C3H/HeJ MGP_C3HHeJ_G0017837
 protein coding gene Chr11:20487028-20490309 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018475
 protein coding gene Chr11:21542764-21546045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016133
 protein coding gene Chr11:18797803-18801131 (+)
CAST/EiJ MGP_CASTEiJ_G0017398
 protein coding gene Chr11:20538980-20542288 (+)
CBA/J MGP_CBAJ_G0017811
 protein coding gene Chr11:22492040-22495327 (+)
DBA/2J MGP_DBA2J_G0017921
 protein coding gene Chr11:19828704-19831985 (+)
FVB/NJ MGP_FVBNJ_G0017913
 protein coding gene Chr11:19604764-19608053 (+)
LP/J MGP_LPJ_G0017992
 protein coding gene Chr11:20801442-20804725 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017939
 protein coding gene Chr11:22971197-22974478 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018516
 protein coding gene Chr11:20720011-20723292 (+)
PWK/PhJ MGP_PWKPhJ_G0017179
 protein coding gene Chr11:19862572-19865777 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016976
 protein coding gene Chr11:20459983-20463300 (+)
WSB/EiJ MGP_WSBEiJ_G0017452
 protein coding gene Chr11:20343912-20347217 (+)



Homology
more
  • Human Ortholog
    ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZRSR2, zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
  • Synonyms
    U2AF1L2, U2AF1-RS2, U2AF1RS2, URP, ZC3H22
  • Links
    NCBI Gene ID: 8233
    neXtProt AC: NX_Q15696
    UniProt: Q15696

  • Chr Location
    Xp22.2; chrX:15790156-15830694 (+)  GRCh38
  • Human Ortholog
    ZRSR2P1, ZRSR2 pseudogene 1
  • Synonyms
    U2AF1L1, U2AF1P, U2AF1-RS1, U2AF1RS1, U2AFBPL, ZC3H21, ZRSR1
  • Links
    NCBI Gene ID: 7310
    UniProt: Q15695

  • Chr Location
    5q22.2; chr5:112891610-112893097 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ZRSR2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Zrsr2-ps1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    13 strains or lines available
Heterozygotes for a targeted null mutation of this imprinted gene are viable and fertile regardless of the parental origin of the mutated allele. Mice inheriting a null allele maternally and a paternal null allele for Zrsr1 fail to develop beyond the 2 cell stage, with very few reaching morula stage and none implanting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    42
  • cDNA Data
    34
  • Literature Summary
    15
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044068 Ensembl Gene Model | MGI Sequence Detail 1287 C57BL/6J ±  kb
transcript ENSMUST00000229075 Ensembl | MGI Sequence Detail 1287 Not Applicable  
polypeptide Q64707 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000018218 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1
    (term hierarchy)
  • InterPro Domains
    IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    IPR035979 RNA-binding domain superfamily
    IPR000504 RNA recognition motif domain
    IPR003954 RNA recognition motif domain, eukaryote
    IPR009145 U2 auxiliary factor small subunit
    IPR000571 Zinc finger, CCCH-type
Molecular
Reagents
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  • All nucleic 60
    Genomic 12
    cDNA 36
    Primer pair 10
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11468, MGD-MRK-15322, MGD-MRK-3013, MGI:7430927
References
more
  • Summaries
    All 64
    Developmental Gene Expression 15
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:333818 Madan V, et al., ZRSR1 co-operates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells. Haematologica. 2022 Mar 1;107(3):680-689
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory