U2af2 MGI Mouse Gene Detail - MGI:98886 - U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

Symbol

U2af2
Name

U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2

Feature Type

protein coding gene
IDs

MGI:98886
NCBI Gene: 22185
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:5065142-5082937 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.93 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98886	protein coding gene	Chr7:5063884-5082937 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031583	protein coding gene	Chr7:2027979-2053107 (+)
A/J	MGP_AJ_G0031557	protein coding gene	Chr7:2025092-2043372 (+)
AKR/J	MGP_AKRJ_G0031486	protein coding gene	Chr7:2102670-2120317 (+)
BALB/cJ	MGP_BALBcJ_G0031565	protein coding gene	Chr7:2063425-2087215 (+)
C3H/HeJ	MGP_C3HHeJ_G0031286	protein coding gene	Chr7:2078930-2098282 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032026	protein coding gene	Chr7:2098045-2123396 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029150	protein coding gene	Chr7:1739063-1757133 (+)
CAST/EiJ	MGP_CASTEiJ_G0030650	protein coding gene	Chr7:2015741-2034708 (+)
CBA/J	MGP_CBAJ_G0031244	protein coding gene	Chr7:2309272-2327623 (+)
DBA/2J	MGP_DBA2J_G0031403	protein coding gene	Chr7:2012722-2025642 (+)
FVB/NJ	MGP_FVBNJ_G0031355	protein coding gene	Chr7:1949756-1968797 (+)
LP/J	MGP_LPJ_G0031488	protein coding gene	Chr7:2124280-2142329 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031394	protein coding gene	Chr7:2260372-2279873 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032056	protein coding gene	Chr7:2003765-2024046 (+)
PWK/PhJ	MGP_PWKPhJ_G0030378	protein coding gene	Chr7:2159355-2176887 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030203	protein coding gene	Chr7:2043908-2061794 (+)
WSB/EiJ	MGP_WSBEiJ_G0030745	protein coding gene	Chr7:2014570-2034794 (+)

Human Ortholog

U2AF2, U2 small nuclear RNA auxiliary factor 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

U2AF2, U2 small nuclear RNA auxiliary factor 2
Synonyms

DEVDFB, U2AF65
Links

HGNC:23156

NCBI Gene ID: 11338

neXtProt AC: NX_P26368

UniProt: P26368
Chr Location

19q13.42; chr19:55654146-55674716 (+) GRCh38

MGI Vertebrate Homology

U2af2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: U2AF2
Gene Tree

U2af2

Diseases

1 with human U2AF2 associations

				Human Disease	Mouse Models
				developmental delay, dysmorphic facies, and brain anomalies IDs developmental delay, dysmorphic facies, and brain anomalies DOID:0060933 OMIM:620535

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
1 images
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

110
Endonuclease-mediated

4
Gene trapped

105
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.

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All GO Annotations

33
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

825
Tissues

38
cDNA Data

116
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase u2af2

ZFIN u2af2b

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All Sequences

83
RefSeq

36
UniProt

7
CCDS

CCDS57476.1, CCDS85208.1

Ensembl

ENSMUSG00000030435 (Evidence)
NCBI Gene

22185

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030435	Ensembl Gene Model \| MGI Sequence Detail	17796	C57BL/6J	± kb
transcript	ENSMUST00000209099	Ensembl \| MGI Sequence Detail	2088	Not Applicable
polypeptide	ENSMUSP00000147013	Ensembl \| MGI Sequence Detail	475	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000016946 splicing factor U2AF 65 kDa subunit

(term hierarchy)
PDB

2M52, 3V4M, 4RU2, 4Z2X, 5CXT
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR006529 U2 snRNP auxilliary factor, large subunit, splicing factor
GlyGen

P26369 1 site, 1 O-linked glycan (1 site)

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All nucleic 117

cDNA 116

Primer pair 1

Microarray probesets 3

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MGD-MRK-15323

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 14
Earliest

J:872 Sailer A, et al., Cloning and sequencing of the murine homologue of the human splicing factor U2AF65. Nucleic Acids Res. 1992 May 11;20(9):2374
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for U2af2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64404	Chr7:5064356-5064382 (+)	-773 bp
Tssr64405	Chr7:5064397-5064410 (+)	-738 bp
Tssr64406	Chr7:5064671-5064751 (+)	-431 bp
Tssr64407	Chr7:5064752-5064761 (+)	-385 bp
Tssr64408	Chr7:5065182-5065240 (+)	69 bp
Tssr64409	Chr7:5065255-5065266 (+)	119 bp
Tssr64410	Chr7:5068063-5068074 (+)	2,927 bp
Tssr64411	Chr7:5068205-5068210 (+)	3,066 bp
Tssr64412	Chr7:5071900-5072001 (+)	6,809 bp
Tssr64413	Chr7:5072004-5072023 (+)	6,872 bp
Tssr64414	Chr7:5072045-5072064 (+)	6,913 bp
Tssr64415	Chr7:5072092-5072109 (+)	6,959 bp
Tssr64416	Chr7:5072148-5072184 (+)	7,024 bp
Tssr64417	Chr7:5072188-5072201 (+)	7,053 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24