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Ubc Gene Detail
Summary
  • Symbol
    Ubc
  • Name
    ubiquitin C
  • Synonyms
    2700054O04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:98889
    NCBI Gene: 22190
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:125463029-125467081 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 64.18 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98889
 protein coding gene Chr5:125463029-125467266 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0030075
 protein coding gene Chr5:123818127-123819522 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030086
 protein coding gene Chr5:125153787-125155157 (-)
C3H/HeJ MGP_C3HHeJ_G0029803
 protein coding gene Chr5:128441489-128442884 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030539
 protein coding gene Chr5:134233411-134234805 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029212
 protein coding gene Chr5:127577430-127578822 (-)
CBA/J MGP_CBAJ_G0029773
 protein coding gene Chr5:139497513-139498908 (-)
DBA/2J MGP_DBA2J_G0029923
 protein coding gene Chr5:123835861-123837256 (-)
FVB/NJ MGP_FVBNJ_G0029879
 protein coding gene Chr5:122909282-122910904 (-)
LP/J MGP_LPJ_G0030012
 protein coding gene Chr5:129751751-129755557 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029910
 protein coding gene Chr5:143009605-143011000 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030580
 protein coding gene Chr5:127451578-127452973 (-)
PWK/PhJ MGP_PWKPhJ_G0028926
 protein coding gene Chr5:122678220-122679615 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028763
 protein coding gene Chr5:125084702-125086285 (-)
WSB/EiJ MGP_WSBEiJ_G0029286
 protein coding gene Chr5:128150263-128151657 (-)



Homology
more
  • Human Ortholog
    UBC, ubiquitin C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBC, ubiquitin C
  • Synonyms
    HMG20
  • Links
    NCBI Gene ID: 7316
    neXtProt AC: NX_P0CG48
    UniProt: P0CG48

  • Chr Location
    12q24.31; chr12:124911604-124917368 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die between E 12.5 and E14.5 most likely due to a severe defect in liver cell proliferation. Mutant MEFs exhibit reduced growth rates, premature senescence, increased apoptosis and delayed cell-cycle progression, and are hypersensitive to proteasome inhibitors and heat shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    10
  • cDNA Data
    20
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22190 NCBI Gene Model | MGI Sequence Detail 4053 C57BL/6J ±  kb
    transcript NM_019639 RefSeq | MGI Sequence Detail 2424 ZRU/MplStud  
    polypeptide P0CG50 UniProt | EBI | MGI Sequence Detail 734 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 1
      cDNA 21
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15327, MGI:1924253, MGI:2140815
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:357839 Nasim S, et al., Multiple cell types including melanocytes contribute to elastogenesis in the developing murine aortic valve. Sci Rep. 2024 Oct 26;14(1):25481
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory