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Uba1y Gene Detail
Summary
  • Symbol
    Uba1y
  • Name
    ubiquitin-activating enzyme, Chr Y
  • Synonyms
    A1s9Y-1, Sby, Ube1y-1, Ube1y1, Ube-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98891
    NCBI Gene: 22202
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrY:818612-843684 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98891
 protein coding gene ChrY:818612-844224 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    31
  • cDNA Data
    7
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22202 NCBI Gene Model | MGI Sequence Detail 25073 C57BL/6J ±  kb
transcript NM_001357043 RefSeq | MGI Sequence Detail 3457 ZRU/MplStud  
polypeptide P31254 UniProt | EBI | MGI Sequence Detail 1058 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000017217 ubiquitin-like modifier-activating enzyme 1 Y
    (term hierarchy)
  • EC
    6.2.1.45
  • InterPro Domains
    IPR045886 ThiF/MoeB/HesA family
    IPR000594 THIF-type NAD/FAD binding fold
    IPR035985 Ubiquitin-activating enzyme
    IPR018075 Ubiquitin-activating enzyme E1
    IPR018074 Ubiquitin-activating enzyme E1, conserved site
    IPR018965 Ubiquitin-activating enzyme E1, C-terminal
    IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamily
    IPR033127 Ubiquitin-activating enzyme E1, Cys active site
    IPR032418 Ubiquitin-activating enzyme E1, FCCH domain
    IPR042302 Ubiquitin-activating enzyme E1, FCCH domain superfamily
    IPR032420 Ubiquitin-activating enzyme E1, four-helix bundle
    IPR042449 Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1
    IPR042063 Ubiquitin-activating enzyme E1, SCCH domain
    IPR019572 Ubiquitin-activating enzyme, SCCH domain
    IPR000011 Ubiquitin/SUMO-activating enzyme E1-like
Molecular
Reagents
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  • All nucleic 32
    Genomic 13
    cDNA 11
    Primer pair 6
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1004, MGD-MRK-14298, MGD-MRK-15329, MGD-MRK-15332, MGD-MRK-15335
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:87880 Finley D, et al., Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell. 1984 May;37(1):43-55
  • Latest
    J:329968 Kazi S, et al., MRNIP interacts with sex body chromatin to support meiotic progression, spermatogenesis, and male fertility in mice. FASEB J. 2022 Sep;36(9):e22479
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory