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Ucp1 Gene Detail
Summary
  • Symbol
    Ucp1
  • Name
    uncoupling protein 1 (mitochondrial, proton carrier)
  • Synonyms
    Slc25a7
  • Feature Type
    protein coding gene
  • IDs
    MGI:98894
    NCBI Gene: 22227
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84016981-84025081 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 39.65 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    303 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98894
 protein coding gene Chr8:84016977-84025085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033828
 protein coding gene Chr8:84081861-84094164 (+)
A/J MGP_AJ_G0033811
 protein coding gene Chr8:80794854-80802920 (+)
AKR/J MGP_AKRJ_G0033737
 protein coding gene Chr8:83178358-83186415 (+)
BALB/cJ MGP_BALBcJ_G0033804
 protein coding gene Chr8:80914004-80922034 (+)
C3H/HeJ MGP_C3HHeJ_G0033513
 protein coding gene Chr8:83811535-83819571 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034324
 protein coding gene Chr8:87337261-87345379 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031265
 protein coding gene Chr8:74639332-74647463 (+)
CAST/EiJ MGP_CASTEiJ_G0032844
 protein coding gene Chr8:83209274-83217296 (+)
CBA/J MGP_CBAJ_G0033492
 protein coding gene Chr8:90434028-90442072 (+)
DBA/2J MGP_DBA2J_G0033645
 protein coding gene Chr8:80439730-80447758 (+)
FVB/NJ MGP_FVBNJ_G0033590
 protein coding gene Chr8:79375173-79383228 (+)
LP/J MGP_LPJ_G0033735
 protein coding gene Chr8:84214607-84222647 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033633
 protein coding gene Chr8:92957153-92965507 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034341
 protein coding gene Chr8:83190453-83201523 (+)
PWK/PhJ MGP_PWKPhJ_G0032547
 protein coding gene Chr8:79671347-79679704 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032385
 protein coding gene Chr8:81989188-81996681 (+)
WSB/EiJ MGP_WSBEiJ_G0032957
 protein coding gene Chr8:83573195-83581242 (+)



Homology
more
  • Human Ortholog
    UCP1, uncoupling protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCP1, uncoupling protein 1
  • Synonyms
    SLC25A7, UCP
  • Links
    NCBI Gene ID: 7350
    neXtProt AC: NX_P25874
    UniProt: P25874

  • Chr Location
    4q31.1; chr4:140559431-140568961 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human UCP1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    208 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit impaired thermoregulation on some genetic backgrounds. Biochemical alterations in brown fat mitochondria are also observed.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    916
  • Tissues
    31
  • cDNA Data
    33
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031710 Ensembl Gene Model | MGI Sequence Detail 8101 C57BL/6J ±  kb
    transcript ENSMUST00000034146 Ensembl | MGI Sequence Detail 1636 Not Applicable  
    polypeptide ENSMUSP00000034146 Ensembl | MGI Sequence Detail 307 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000017035 mitochondrial brown fat uncoupling protein 1
      (term hierarchy)
    • InterPro Domains
      IPR023395 Mitochondrial carrier domain superfamily
      IPR002067 Mitochondrial carrier protein
      IPR050391 Mitochondrial Metabolite Transporter
      IPR018108 Mitochondrial substrate/solute carrier
    • GlyGen
      P12242 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 1
      cDNA 36
      Primer pair 18
      Other 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15339, MGI:2142517
    References
    more
    • Summaries
      All 444
      Developmental Gene Expression 83
      Gene Ontology 21
      Phenotypes 208
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:358826 Zhao J, et al., Myeloid-derived suppressor cells in the tumor microenvironment reduce uncoupling protein 1 expression to boost immunosuppressive activity. Biochem Biophys Res Commun. 2024 Nov 5;732:150408
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory