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Usp4 Gene Detail
Summary
  • Symbol
    Usp4
  • Name
    ubiquitin specific peptidase 4 (proto-oncogene)
  • Synonyms
    F730026I20Rik, Unp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98905
    NCBI Gene: 22258
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108225052-108269744 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.25 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1196 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98905
 protein coding gene Chr9:108223763-108269744 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035294
 protein coding gene Chr9:110298364-110347534 (+)
A/J MGP_AJ_G0035273
 protein coding gene Chr9:106258632-106303227 (+)
AKR/J MGP_AKRJ_G0035205
 protein coding gene Chr9:108913156-108959620 (+)
BALB/cJ MGP_BALBcJ_G0035267
 protein coding gene Chr9:105954790-105999562 (+)
C3H/HeJ MGP_C3HHeJ_G0034977
 protein coding gene Chr9:109307293-109352630 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035787
 protein coding gene Chr9:113296986-113346070 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032685
 protein coding gene Chr9:103688837-103735220 (+)
CAST/EiJ MGP_CASTEiJ_G0034288
 protein coding gene Chr9:109278498-109323333 (+)
CBA/J MGP_CBAJ_G0034945
 protein coding gene Chr9:117292290-117349124 (+)
DBA/2J MGP_DBA2J_G0035106
 protein coding gene Chr9:105713300-105758952 (+)
FVB/NJ MGP_FVBNJ_G0035054
 protein coding gene Chr9:104479697-104525441 (+)
LP/J MGP_LPJ_G0035182
 protein coding gene Chr9:110497805-110544355 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035093
 protein coding gene Chr9:118877149-118923113 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035808
 protein coding gene Chr9:109203149-109247371 (+)
PWK/PhJ MGP_PWKPhJ_G0033995
 protein coding gene Chr9:106040977-106086841 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033830
 protein coding gene Chr9:109249200-109300213 (+)
WSB/EiJ MGP_WSBEiJ_G0034409
 protein coding gene Chr9:109079306-109127907 (+)



Homology
more
  • Human Ortholog
    USP4, ubiquitin specific peptidase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP4, ubiquitin specific peptidase 4
  • Synonyms
    UNP, Unph
  • Links
    NCBI Gene ID: 7375
    neXtProt AC: NX_Q13107
    UniProt: Q13107

  • Chr Location
    3p21.31; chr3:49277144-49340712 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased irradiation-induced apoptosis, slow cellular growth, resistance to oncogenic transformation, and early cellular replicative senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032612 Ensembl Gene Model | MGI Sequence Detail 44693 C57BL/6J ±  kb
    transcript ENSMUST00000035237 Ensembl | MGI Sequence Detail 3662 Not Applicable  
    polypeptide ENSMUSP00000035237 Ensembl | MGI Sequence Detail 962 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000017179 ubiquitin carboxyl-terminal hydrolase 4
      (term hierarchy)
    • PDB
      3JYU
    • EC
      3.4.19.12
    • InterPro Domains
      IPR035927 DUSP-like superfamily
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
      IPR050185 Ubiquitin carboxyl-terminal hydrolase
      IPR028135 Ubiquitin-like domain, USP-type
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    • GlyGen
      P35123 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 5
      cDNA 22
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15356, MGI:2444466
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 16
    • Earliest
      J:13201 Gupta K, et al., Unp, a mouse gene related to the tre oncogene. Oncogene. 1993 Aug;8(8):2307-10
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory