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Upk1b Gene Detail
Summary
  • Symbol
    Upk1b
  • Name
    uroplakin 1B
  • Synonyms
    Tspan20, Upk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98912
    NCBI Gene: 22268
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38593544-38620565 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.87 cM, cytoband B5-C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    777 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98912
 protein coding gene Chr16:38593544-38620690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022822
 protein coding gene Chr16:37314720-37342598 (-)
A/J MGP_AJ_G0022787
 protein coding gene Chr16:35470937-35497031 (-)
AKR/J MGP_AKRJ_G0022759
 protein coding gene Chr16:36812428-36839216 (-)
BALB/cJ MGP_BALBcJ_G0022788
 protein coding gene Chr16:35583531-35613022 (-)
C3H/HeJ MGP_C3HHeJ_G0022552
 protein coding gene Chr16:36917042-36944468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023235
 protein coding gene Chr16:38173363-38204376 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020750
 protein coding gene Chr16:35848291-35875094 (-)
CAST/EiJ MGP_CASTEiJ_G0022078
 protein coding gene Chr16:37077889-37106123 (-)
CBA/J MGP_CBAJ_G0022523
 protein coding gene Chr16:39839270-39873501 (-)
DBA/2J MGP_DBA2J_G0022655
 protein coding gene Chr16:35347374-35375922 (-)
FVB/NJ MGP_FVBNJ_G0022630
 protein coding gene Chr16:35375410-35401091 (-)
LP/J MGP_LPJ_G0022723
 protein coding gene Chr16:36991772-37022455 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022649
 protein coding gene Chr16:38934410-38963758 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023250
 protein coding gene Chr16:36786892-36815119 (-)
PWK/PhJ MGP_PWKPhJ_G0021818
 protein coding gene Chr16:35765516-35793232 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021649
 protein coding gene Chr16:36670434-36696986 (-)
WSB/EiJ MGP_WSBEiJ_G0022122
 protein coding gene Chr16:36846055-36873708 (-)



Homology
more
  • Human Ortholog
    UPK1B, uroplakin 1B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK1B, uroplakin 1B
  • Synonyms
    TSPAN20, UPIB, UPK1
  • Links
    NCBI Gene ID: 7348
    neXtProt AC: NX_O75841
    UniProt: O75841

  • Chr Location
    3q13.32; chr3:119173517-119205143 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Mice heterozygous for a reporter allele are viable, fertile, and physically and behaviorally normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1254
  • Tissues
    203
  • cDNA Data
    17
  • Literature Summary
    30
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22268 NCBI Gene Model | MGI Sequence Detail 27022 C57BL/6J ±  kb
transcript NM_178924 RefSeq | MGI Sequence Detail 1769 C57BL/6  
polypeptide Q9Z2C6 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 18
    Primer pair 4
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15365, MGD-MRK-15367, MGI:2146422
References
more
  • Summaries
    All 70
    Developmental Gene Expression 30
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory