Upk3a MGI Mouse Gene Detail - MGI:98914

Symbol

Upk3a
Name

uroplakin 3A
Synonyms

1110017C07Rik, Upk3

Feature Type

protein coding gene
IDs

MGI:98914
NCBI Gene: 22270
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:84901342-84906748 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 40.25 cM, cytoband E3
Mapping Data

2 experiments

SNPs within 2kb

253 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98914	protein coding gene	Chr15:84901342-84906761 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022186	protein coding gene	Chr15:85836442-85841861 (+)
A/J	MGP_AJ_G0022145	protein coding gene	Chr15:82669470-82674889 (+)
AKR/J	MGP_AKRJ_G0022120	protein coding gene	Chr15:85112487-85117909 (+)
BALB/cJ	MGP_BALBcJ_G0022151	protein coding gene	Chr15:82792984-82798403 (+)
C3H/HeJ	MGP_C3HHeJ_G0021921	protein coding gene	Chr15:85042051-85047470 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022596	protein coding gene	Chr15:89097986-89103405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020121	protein coding gene	Chr15:79016097-79021592 (+)
CAST/EiJ	MGP_CASTEiJ_G0021443	protein coding gene	Chr15:85820910-85842973 (+)
CBA/J	MGP_CBAJ_G0021888	protein coding gene	Chr15:91994267-91999686 (+)
DBA/2J	MGP_DBA2J_G0022015	protein coding gene	Chr15:82139646-82144874 (+)
FVB/NJ	MGP_FVBNJ_G0021994	protein coding gene	Chr15:81211324-81216743 (+)
LP/J	MGP_LPJ_G0022086	protein coding gene	Chr15:85999537-86004956 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022014	protein coding gene	Chr15:96773472-96778894 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022611	protein coding gene	Chr15:85105040-85110459 (+)
PWK/PhJ	MGP_PWKPhJ_G0021184	protein coding gene	Chr15:82146968-82152202 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021018	protein coding gene	Chr15:84813153-84818580 (+)
WSB/EiJ	MGP_WSBEiJ_G0021492	protein coding gene	Chr15:85599667-85604895 (+)

Human Ortholog

UPK3A, uroplakin 3A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UPK3A, uroplakin 3A
Synonyms

UP3A, UPIII, UPIIIA, UPK3
Links

HGNC:12580

NCBI Gene ID: 7380

neXtProt AC: NX_O75631

UniProt: O75631
Chr Location

22q13.31; chr22:45284949-45295874 (+) GRCh38

MGI Vertebrate Homology

Upk3a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: UPK3A
Gene Tree

Upk3a

Diseases

1 with Upk3a mouse models

Human Disease

Mouse Models

vesicoureteral reflux

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
5 images
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Upk3a
Incidental Mutations

APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit urogenital defects including abnormal urothelium, vesicoureteral reflux, and hydronephrosis.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1063
Tissues

230
cDNA Data

13
Literature Summary

42

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase upk3a

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All Sequences

34
RefSeq

2
UniProt

2
CCDS

CCDS27716.1

Ensembl

ENSMUSG00000022435 (Evidence)
NCBI Gene

22270

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022435	Ensembl Gene Model \| MGI Sequence Detail	5407	C57BL/6J	± kb
transcript	ENSMUST00000023070	Ensembl \| MGI Sequence Detail	1093	Not Applicable
polypeptide	ENSMUSP00000023070	Ensembl \| MGI Sequence Detail	287	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000017115 uroplakin-3a

(term hierarchy)
InterPro Domains

IPR024831 Uroplakin-3

IPR024825 Uroplakin-3a
GlyGen

Q9JKX8 3 sites

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All nucleic 21

cDNA 14

Primer pair 5

Other 2

Microarray probesets 3

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MGD-MRK-15369, MGI:1915869

Summaries

All 97

Developmental Gene Expression 42

Diseases 2

Gene Ontology 8

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:330441 Ortega MA, et al., Exocyst inactivation in urothelial cells disrupts autophagy and activates non-canonical NF-kappaB signaling. Dis Model Mech. 2022 Oct 1;15(10):dmm049785

TSS for Upk3a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr4679	Chr15:84901334-84901335 (+)	-7 bp
Tssr132485	Chr15:84901339-84901342 (+)	-1 bp
Tssr132486	Chr15:84901364-84901401 (+)	41 bp
Tssr132487	Chr15:84901408-84901413 (+)	69 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24