About   Help   FAQ
Scgb1a1 Gene Detail
Summary
  • Symbol
    Scgb1a1
  • Name
    secretoglobin, family 1A, member 1
  • Synonyms
    Blastokinin, CC10, CC16, CCSP, club cell secretory protein, PCB-BP, UG, Utg
  • Feature Type
    protein coding gene
  • IDs
    MGI:98919
    NCBI Gene: 22287
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:9061006-9065320 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.05 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98919
 protein coding gene Chr19:9061000-9065322 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024829
 protein coding gene Chr19:6379744-6384066 (-)
A/J MGP_AJ_G0024797
 protein coding gene Chr19:6037431-6041755 (-)
AKR/J MGP_AKRJ_G0024772
 protein coding gene Chr19:6144685-6149007 (-)
BALB/cJ MGP_BALBcJ_G0024797
 protein coding gene Chr19:6147164-6151966 (-)
C3H/HeJ MGP_C3HHeJ_G0024563
 protein coding gene Chr19:6238227-6242539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025244
 protein coding gene Chr19:6532181-6536489 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022673
 protein coding gene Chr19:6291904-6296219 (-)
CAST/EiJ MGP_CASTEiJ_G0024036
 protein coding gene Chr19:5892496-5898730 (-)
CBA/J MGP_CBAJ_G0024537
 protein coding gene Chr19:6635667-6640059 (-)
DBA/2J MGP_DBA2J_G0024664
 protein coding gene Chr19:5878569-5883124 (-)
FVB/NJ MGP_FVBNJ_G0024631
 protein coding gene Chr19:5936401-5940697 (-)
LP/J MGP_LPJ_G0024751
 protein coding gene Chr19:6283035-6287347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024658
 protein coding gene Chr19:6488410-6492658 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025293
 protein coding gene Chr19:6186748-6191433 (-)
PWK/PhJ MGP_PWKPhJ_G0023781
 protein coding gene Chr19:5557015-5561743 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023586
 protein coding gene Chr19:5796103-5800270 (-)
WSB/EiJ MGP_WSBEiJ_G0024098
 protein coding gene Chr19:6158912-6163229 (-)



Homology
more
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCGB1A1, secretoglobin family 1A member 1
  • Synonyms
    CC10, CC16, CCPBP, CCSP, UGB, UP-1, UP1
  • Links
    NCBI Gene ID: 7356
    neXtProt AC: NX_P11684
    UniProt: P11684

  • Chr Location
    11q12.3; chr11:62405103-62423195 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scgb1a1 mouse models; 3 with human SCGB1A1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 6 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    151 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit progressive renal glomerular disease characterized by proteinuria and hypocalcemia, necrotic pancreatic foci, reduced pulmonary neuroendocrine bodies, weight loss, cachexia, and premature mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1015
  • Tissues
    61
  • cDNA Data
    269
  • Literature Summary
    284
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22287 NCBI Gene Model | MGI Sequence Detail 4315 C57BL/6J ±  kb
    transcript NM_011681 RefSeq | MGI Sequence Detail 468 C57BL/6  
    polypeptide Q06318 UniProt | EBI | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 298
      Genomic 4
      cDNA 272
      Primer pair 13
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15376
    References
    more
    • Summaries
      All 467
      Developmental Gene Expression 284
      Diseases 1
      Gene Ontology 9
      Phenotypes 151
    • Earliest
      J:640 Sandmoller A, et al., Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice. Mech Dev. 1991 Mar;34(1):57-67
    • Latest
      J:354988 Lingamallu SM, et al., Neuroepithelial bodies and terminal bronchioles are niches for distinctive club cells that repair the airways following acute notch inhibition. Cell Rep. 2024 Sep 24;43(9):114654
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory