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Vip Gene Detail
Summary
  • Symbol
    Vip
  • Name
    vasoactive intestinal polypeptide
  • Synonyms
    PHI, peptide histidine isoleucine
  • Feature Type
    protein coding gene
  • IDs
    MGI:98933
    NCBI Gene: 22353
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:5589218-5597617 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 1.97 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    297 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98933
 protein coding gene Chr10:5589131-5597617 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016985
 protein coding gene Chr10:2721872-2730270 (+)
A/J MGP_AJ_G0016963
 protein coding gene Chr10:2563262-2571656 (+)
AKR/J MGP_AKRJ_G0016928
 protein coding gene Chr10:2574155-2582554 (+)
BALB/cJ MGP_BALBcJ_G0016921
 protein coding gene Chr10:2540765-2549156 (+)
C3H/HeJ MGP_C3HHeJ_G0016746
 protein coding gene Chr10:2703593-2711989 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017384
 protein coding gene Chr10:2765202-2773598 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015090
 protein coding gene Chr10:2330251-2338666 (+)
CAST/EiJ MGP_CASTEiJ_G0016328
 protein coding gene Chr10:2737634-2746037 (+)
CBA/J MGP_CBAJ_G0016718
 protein coding gene Chr10:2889339-2897733 (+)
DBA/2J MGP_DBA2J_G0016826
 protein coding gene Chr10:2549870-2558278 (+)
FVB/NJ MGP_FVBNJ_G0016821
 protein coding gene Chr10:2502530-2510926 (+)
LP/J MGP_LPJ_G0016901
 protein coding gene Chr10:2650471-2658868 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016852
 protein coding gene Chr10:2743090-2751662 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017421
 protein coding gene Chr10:2616297-2624694 (+)
PWK/PhJ MGP_PWKPhJ_G0016114
 protein coding gene Chr10:2561731-2570221 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015896
 protein coding gene Chr10:2813037-2821445 (+)
WSB/EiJ MGP_WSBEiJ_G0016390
 protein coding gene Chr10:2671319-2679710 (+)



Homology
more
  • Human Ortholog
    VIP, vasoactive intestinal peptide
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VIP, vasoactive intestinal peptide
  • Synonyms
    PHM27
  • Links
    NCBI Gene ID: 7432
    neXtProt AC: NX_P01282
    UniProt: P01282

  • Chr Location
    6q25.2; chr6:152750797-152759765 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vip mouse models; 2 with human VIP associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    338 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display abnormal circadian rhythyms with a shorter period, abnormal phase, and in 1/4 arrhythmic circadian persistence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1005
  • Tissues
    246
  • cDNA Data
    13
  • Literature Summary
    91
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019772 Ensembl Gene Model | MGI Sequence Detail 8400 C57BL/6J ±  kb
    transcript ENSMUST00000019906 Ensembl | MGI Sequence Detail 1530 Not Applicable  
    polypeptide ENSMUSP00000019906 Ensembl | MGI Sequence Detail 171 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 4
      cDNA 13
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15398
    References
    more
    • Summaries
      All 480
      Developmental Gene Expression 91
      Diseases 1
      Gene Ontology 7
      Phenotypes 338
    • Earliest
      J:11160 Lamperti ED, et al., Characterization of the gene and messages for vasoactive intestinal polypeptide (VIP) in rat and mouse. Brain Res Mol Brain Res. 1991 Feb;9(3):217-31
    • Latest
      J:359036 Lin ZJ, et al., Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model. J Clin Invest. 2024 Sep 24;134(22)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory