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Vldlr Gene Detail
Summary
  • Symbol
    Vldlr
  • Name
    very low density lipoprotein receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:98935
    NCBI Gene: 22359
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
  • Candidate for QTL
    6 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:27193884-27231631 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 21.77 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1148 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98935
 protein coding gene Chr19:27190070-27231631 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025007
 protein coding gene Chr19:25573821-25613134 (+)
A/J MGP_AJ_G0024984
 protein coding gene Chr19:24242850-24280554 (+)
AKR/J MGP_AKRJ_G0024952
 protein coding gene Chr19:25159030-25198598 (+)
BALB/cJ MGP_BALBcJ_G0024983
 protein coding gene Chr19:24294321-24331944 (+)
C3H/HeJ MGP_C3HHeJ_G0024739
 protein coding gene Chr19:25132639-25171001 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025424
 protein coding gene Chr19:26311096-26348732 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022843
 protein coding gene Chr19:24272153-24309725 (+)
CAST/EiJ MGP_CASTEiJ_G0024209
 protein coding gene Chr19:24904082-24943850 (+)
CBA/J MGP_CBAJ_G0024717
 protein coding gene Chr19:27554626-27596300 (+)
DBA/2J MGP_DBA2J_G0024849
 protein coding gene Chr19:24217823-24256382 (+)
FVB/NJ MGP_FVBNJ_G0024811
 protein coding gene Chr19:24067576-24106331 (+)
LP/J MGP_LPJ_G0024934
 protein coding gene Chr19:25558063-25597282 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024838
 protein coding gene Chr19:27487300-27525750 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025479
 protein coding gene Chr19:25167703-25206245 (+)
PWK/PhJ MGP_PWKPhJ_G0023957
 protein coding gene Chr19:23866360-23904723 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023761
 protein coding gene Chr19:24388016-24425698 (+)
WSB/EiJ MGP_WSBEiJ_G0024276
 protein coding gene Chr19:25185710-25223391 (+)



Homology
more
  • Human Ortholog
    VLDLR, very low density lipoprotein receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VLDLR, very low density lipoprotein receptor
  • Synonyms
    CAMRQ1, CARMQ1, CHRMQ1, VLDL-R, VLDLRCH
  • Links
    NCBI Gene ID: 7436
    neXtProt AC: NX_P98155
    UniProt: P98155

  • Chr Location
    9p24.2; chr9:2621182-2660056 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vldlr mouse models; 3 with human VLDLR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 6 alleles in 9 genetic backgrounds
    27 phenotypes from multigenic genotypes
    122 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation. Abnormal retinal vascularization is also found.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1175
  • Tissues
    221
  • cDNA Data
    117
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024924 Ensembl Gene Model | MGI Sequence Detail 37748 C57BL/6J ±  kb
    transcript ENSMUST00000167487 Ensembl | MGI Sequence Detail 7971 Not Applicable  
    polypeptide ENSMUSP00000127329 Ensembl | MGI Sequence Detail 873 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017305 very low-density lipoprotein receptor
      (term hierarchy)
    • InterPro Domains
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR000033 LDLR class B repeat
      IPR036055 LDL receptor-like superfamily
      IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
      IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
      IPR050685 Low-density lipoprotein receptor
      IPR051221 Low-density lipoprotein receptor-related
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR011042 Six-bladed beta-propeller, TolB-like
    • GlyGen
      P98156 3 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 133
      Genomic 2
      cDNA 120
      Primer pair 9
      Other 2

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-15401, MGI:2147441, MGI:2147548, MGI:2147687
    References
    more
    • Summaries
      All 234
      Developmental Gene Expression 49
      Diseases 1
      Gene Ontology 17
      Phenotypes 122
    • Earliest
      J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
    • Latest
      J:358325 Deng F, et al., CircSlc17a5 controlled by VLDLR/QKI pathway regulated the choroidal angiogenesis. Biochim Biophys Acta Mol Cell Res. 2024 Jul 26;1871(7):119802
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory