Vpreb3 MGI Mouse Gene Detail - MGI:98938 - V-set pre-B cell surrogate light chain 3

Symbol

Vpreb3
Name

V-set pre-B cell surrogate light chain 3
Synonyms

8HS-20, Vpreb-3

Feature Type

protein coding gene
IDs

MGI:98938
NCBI Gene: 22364
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr10:75778891-75785491 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 38.63 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98938	protein coding gene	Chr10:75778859-75785491 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017373	protein coding gene	Chr10:76145415-76151779 (+)
A/J	MGP_AJ_G0017350	protein coding gene	Chr10:73526600-73534127 (+)
AKR/J	MGP_AKRJ_G0017311	protein coding gene	Chr10:75501039-75509409 (+)
BALB/cJ	MGP_BALBcJ_G0017310	protein coding gene	Chr10:73724277-73730627 (+)
C3H/HeJ	MGP_C3HHeJ_G0017134	protein coding gene	Chr10:75549592-75556201 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017768	protein coding gene	Chr10:78837939-78844289 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015458	protein coding gene	Chr10:69977779-69984372 (+)
CAST/EiJ	MGP_CASTEiJ_G0016705	protein coding gene	Chr10:75866257-75872830 (+)
CBA/J	MGP_CBAJ_G0017106	protein coding gene	Chr10:81909197-81915563 (+)
DBA/2J	MGP_DBA2J_G0017211	protein coding gene	Chr10:72826260-72832899 (+)
FVB/NJ	MGP_FVBNJ_G0017204	protein coding gene	Chr10:71992882-71999432 (+)
LP/J	MGP_LPJ_G0017284	protein coding gene	Chr10:76646365-76652816 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017232	protein coding gene	Chr10:84001968-84008839 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017807	protein coding gene	Chr10:75536144-75542737 (+)
PWK/PhJ	MGP_PWKPhJ_G0016488	protein coding gene	Chr10:72655245-72661787 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016271	protein coding gene	Chr10:74789247-74795876 (+)
WSB/EiJ	MGP_WSBEiJ_G0016768	protein coding gene	Chr10:75518847-75526464 (+)

Human Ortholog

VPREB3, V-set pre-B cell surrogate light chain 3

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

VPREB3, V-set pre-B cell surrogate light chain 3
Synonyms

8HS20, N27C7-2
Links

HGNC:12710

NCBI Gene ID: 29802

neXtProt AC: NX_Q9UKI3

UniProt: Q9UKI3
Chr Location

22q11.23; chr22:23752743-23754425 (-) GRCh38

MGI Vertebrate Homology

Vpreb3 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: VPREB3
Gene Tree

Vpreb3

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

27
Targeted

3
Genomic Mutations

1 involving Vpreb3
Incidental Mutations

APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

8
UniProt

2
CCDS

CCDS23940.1

Ensembl

ENSMUSG00000000903 (Evidence)
NCBI Gene

22364

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000903	Ensembl Gene Model \| MGI Sequence Detail	6601	C57BL/6J	± kb
transcript	ENSMUST00000121151	Ensembl \| MGI Sequence Detail	729	Not Applicable
polypeptide	ENSMUSP00000113205	Ensembl \| MGI Sequence Detail	130	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR050150 Immunoglobulin Variable Light Chain

IPR013106 Immunoglobulin V-set domain

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All nucleic 23

Genomic 4

cDNA 19

Microarray probesets 4

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MGD-MRK-15411, MGD-MRK-15414, MGI:2143638

Summaries

All 40

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Vpreb3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94159	Chr10:75778854-75778862 (+)	-33 bp
Tssr94160	Chr10:75778880-75778897 (+)	-2 bp
Tssr94161	Chr10:75784126-75784167 (+)	5,256 bp
Tssr94162	Chr10:75784169-75784187 (+)	5,287 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24