xn Gene Detail

Summary

• Symbol
  xn
• Name
  exencephaly
• Synonyms
  hn

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:99134
  NCBI Gene: 22588
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  1
• Chemically induced (other)
  1
• Find Mice (IMSR)
  0 strains or lines available

Homozygotes for a mutation arising in DDT exposed mice exhibit mild to severe exencephaly due to failure of cephalic region of neural tube to close. Mutant pups die neonatally. Penetrance varies from 33-84% and is 2-fold higher in females than males.

Sequences &
Gene Models

• NCBI Gene
  22588

Other
Accession IDs

MGD-MRK-10802, MGD-MRK-15797

References

• Summaries
  All 4

  Phenotypes 3
• Earliest
  J:6099 Wallace ME, et al., Inheritance and morphology of exencephaly, a neonatal lethal recessive with partial penetrance, in the house mouse. Genet Res. 1978 Oct;32(2):135-49