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Yy1
Gene Detail
Symbol

Name
ID
Yy1
YY1 transcription factor
MGI:99150
STS
Synonyms
delta transcription factor, NF-E1, UCRBP transcription factor, Yin Yang 1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
59.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:108792973-108816632 bp, + strand
From VEGA annotation of GRCm38

  23660 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: YY1
Protein SuperFamily: transcription factor yin and yang
Gene Tree: Yy1

Human
homologs
YY1, YY1 transcription factor
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7528
neXtProt AC: NX_P25490

Human Synonyms: DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1

Human Chr (Location): 14q; chr14:100238765-100279034 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die in utero shortly after implantation. Incomplete penetrance of embryonic growth retardation and exencephaly are observed in haploinsufficient mice.
 
Interactions
Yy1 interacts with 191 markers (Mir16-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process anterior/posterior pattern specification, camera-type eye morphogenesis, ...
Component cytoplasm, Ino80 complex, ...
Function DNA binding, enhancer sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (218)    Tissues (182)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
RT-PCR 75
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA YY1 ; Xenbase yy1 ; ZFIN yy1a    NEW 
Molecular
reagents
All nucleic(21) Genomic(7) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000017257 (Evidence)
Ensembl Gene Model ENSMUSG00000021264 (Evidence)
Entrez Gene 22632 (Evidence)
DFCI TC1575787, TC1620915, TC1623487
DoTS DT.101736578, DT.40153084, DT.536174, DT.97372543
NIA Mouse Gene Index U061571
Consensus CDS Project CCDS26163.1
International Mouse Phenotyping Consortium Status Yy1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017257 VEGA Gene Model | MGI Sequence Detail 23660 C57BL/6J ±  kb
transcript OTTMUST00000041760 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000018770 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017114 Transcription factor yin/yang
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017553 transcriptional repressor protein YY1
References
(Earliest) J:13111 Safrany G, et al., Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5559-63
(Latest) J:221142 Beketaev I, et al., Critical role of YY1 in cardiac morphogenesis. Dev Dyn. 2015 May;244(5):669-80
All references(112)
Other
accession IDs
MGD-MRK-15848, MGI:2145026

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory