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Yy1
Gene Detail
Symbol

Name
ID
Yy1
YY1 transcription factor
MGI:99150
STS
Synonyms
delta transcription factor, NF-E1, UCRBP transcription factor, Yin Yang 1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
59.58 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr12:108792973-108816632 bp, + strand
From VEGA annotation of GRCm38

  23660 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2556  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor yin and yang
Gene Tree: Yy1

Human
homologs
Human Homolog YY1, YY1 transcription factor
NCBI Gene ID 7528
neXtProt AC  NX_P25490
Human Synonyms  DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1
Human Chr (Location)  14q; chr14:100238765-100279034 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(13) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die in utero shortly after implantation. Incomplete penetrance of embryonic growth retardation and exencephaly are observed in haploinsufficient mice.
 
Interactions
Yy1 interacts with 192 markers (Mir16-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process anterior/posterior pattern specification, camera-type eye morphogenesis, ...
Component cytoplasm, Ino80 complex, ...
Function DNA binding, four-way junction DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (218)    Tissues (182)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
RT-PCR 75
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(7) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017257 (Evidence)
Ensembl Gene ModelENSMUSG00000021264 (Evidence)
Entrez Gene22632 (Evidence)
DFCITC1575787, TC1620915, TC1623487
DoTSDT.101736578, DT.40153084, DT.536174, DT.97372543
NIA Mouse Gene IndexU061571
Consensus CDS ProjectCCDS26163.1
International Mouse Knockout Project StatusYy1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017257 VEGA Gene Model | MGI Sequence Detail 23660 C57BL/6J ±  kb
transcript OTTMUST00000041760 VEGA | MGI Sequence Detail 2662 Not Applicable 
polypeptide OTTMUSP00000018770 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017114 Transcription factor yin/yang
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017553 transcriptional repressor protein YY1
References
(Earliest) J:13111 Safrany G, et al., Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5559-63
(Latest) J:213006 Verdeguer F, et al., Decreased genetic dosage of hepatic Yin Yang 1 causes diabetic-like symptoms. Mol Endocrinol. 2014 Mar;28(3):308-16
All references(109)
Other
accession IDs
MGD-MRK-15848, MGI:2145026

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory