Pcgf2 MGI Mouse Gene Detail - MGI:99161 - polycomb group ring finger 2

Symbol

Pcgf2
Name

polycomb group ring finger 2
Synonyms

mel-18, Mel18, Rnf110, Zfp144

Feature Type

protein coding gene
IDs

MGI:99161
NCBI Gene: 22658
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:97579649-97591323 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.06 cM, cytoband C1-C3
Mapping Data

6 experiments

SNPs within 2kb

275 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99161	protein coding gene	Chr11:97579647-97593260 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019036	protein coding gene	Chr11:100145393-100158803 (-)
A/J	MGP_AJ_G0019004	protein coding gene	Chr11:96010881-96023717 (-)
AKR/J	MGP_AKRJ_G0018974	protein coding gene	Chr11:98997434-99007587 (-)
BALB/cJ	MGP_BALBcJ_G0018977	protein coding gene	Chr11:96511873-96523999 (-)
C3H/HeJ	MGP_C3HHeJ_G0018791	protein coding gene	Chr11:99111311-99123990 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019430	protein coding gene	Chr11:103236613-103246207 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017061	protein coding gene	Chr11:93465991-93476500 (-)
CAST/EiJ	MGP_CASTEiJ_G0018345	protein coding gene	Chr11:99979038-99990225 (-)
CBA/J	MGP_CBAJ_G0018762	protein coding gene	Chr11:107500983-107512430 (-)
DBA/2J	MGP_DBA2J_G0018870	protein coding gene	Chr11:95562882-95574422 (-)
FVB/NJ	MGP_FVBNJ_G0018859	protein coding gene	Chr11:95056477-95069556 (-)
LP/J	MGP_LPJ_G0018940	protein coding gene	Chr11:100651917-100665620 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018886	protein coding gene	Chr11:107338411-107352377 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019470	protein coding gene	Chr11:99293889-99309537 (-)
PWK/PhJ	MGP_PWKPhJ_G0018117	protein coding gene	Chr11:96548095-96560809 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017907	protein coding gene	Chr11:99012260-99022811 (-)
WSB/EiJ	MGP_WSBEiJ_G0018395	protein coding gene	Chr11:99202657-99215942 (-)

Human Ortholog

PCGF2, polycomb group ring finger 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PCGF2, polycomb group ring finger 2
Synonyms

MEL-18, RNF110, TPFS, ZNF144
Links

HGNC:12929

NCBI Gene ID: 7703

neXtProt AC: NX_P35227

UniProt: P35227
Chr Location

17q12; chr17:38733898-38749817 (-) GRCh38

MGI Vertebrate Homology

Pcgf2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PCGF2
Gene Tree

Pcgf2

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Phenotype Summary

29 phenotypes from 3 alleles in 5 genetic backgrounds
44 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

2
Gene trapped

30
Targeted

10
Genomic Mutations

1 involving Pcgf2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants exhibit multiple abnormalities of the axial skeleton (including homeotic transformations), grow markedly slower, and die either perinatally or between 3-6 weeks of age depending on genetic background.

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All GO Annotations

38
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

80
cDNA Data

44
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pcgf2

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All Sequences

61
RefSeq

16
UniProt

2
CCDS

CCDS25327.1

Ensembl

ENSMUSG00000018537 (Evidence)
NCBI Gene

22658

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018537	Ensembl Gene Model \| MGI Sequence Detail	11675	C57BL/6J	± kb
transcript	ENSMUST00000179765	Ensembl \| MGI Sequence Detail	2485	Not Applicable
polypeptide	ENSMUSP00000137517	Ensembl \| MGI Sequence Detail	342	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000012411 Polycomb group RING finger protein 2

(term hierarchy)
InterPro Domains

IPR032443 RAWUL domain

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site

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All nucleic 49

Genomic 5

cDNA 44

Microarray probesets 4

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MGD-MRK-15913

Summaries

All 106

Developmental Gene Expression 18

Gene Ontology 18

Phenotypes 42
Earliest

J:37393 Croyle ML, et al., Analysis of the organization and nucleotide sequence of the chromosomal gene for the beta-subunit of rat thyrotropin. DNA. 1986 Aug;5(4):299-304
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pcgf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110476	Chr11:97591153-97591175 (-)	159 bp
Tssr110475	Chr11:97590526-97590535 (-)	792 bp
Tssr110474	Chr11:97590460-97590524 (-)	831 bp
Tssr110473	Chr11:97590381-97590398 (-)	933 bp
Tssr110472	Chr11:97581169-97581184 (-)	10,146 bp
Tssr110471	Chr11:97580934-97580991 (-)	10,360 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24