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Zp2 Gene Detail
Summary
  • Symbol
    Zp2
  • Name
    zona pellucida glycoprotein 2
  • Synonyms
    Zp-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99214
    NCBI Gene: 22787
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:119725995-119744514 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.38 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    645 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99214
 protein coding gene Chr7:119725985-119744514 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032924
 protein coding gene Chr7:124086477-124102784 (-)
A/J MGP_AJ_G0032907
 protein coding gene Chr7:120868337-120881864 (-)
AKR/J MGP_AKRJ_G0032839
 protein coding gene Chr7:123987729-124000404 (-)
BALB/cJ MGP_BALBcJ_G0032912
 protein coding gene Chr7:120597501-120612989 (-)
C3H/HeJ MGP_C3HHeJ_G0032622
 protein coding gene Chr7:123892219-123905243 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033418
 protein coding gene Chr7:128982605-128997918 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030390
 protein coding gene Chr7:122287563-122301294 (-)
CAST/EiJ MGP_CASTEiJ_G0031950
 protein coding gene Chr7:115649137-115663677 (-)
CBA/J MGP_CBAJ_G0032595
 protein coding gene Chr7:133295288-133311834 (-)
DBA/2J MGP_DBA2J_G0032747
 protein coding gene Chr7:118919988-118933049 (-)
FVB/NJ MGP_FVBNJ_G0032700
 protein coding gene Chr7:118748568-118763165 (-)
LP/J MGP_LPJ_G0032841
 protein coding gene Chr7:125534729-125547940 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032732
 protein coding gene Chr7:134746250-134760051 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033438
 protein coding gene Chr7:122970376-122987316 (-)
PWK/PhJ MGP_PWKPhJ_G0031658
 protein coding gene Chr7:111831727-111846567 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031504
 protein coding gene Chr7:109719585-109733358 (-)
WSB/EiJ MGP_WSBEiJ_G0032063
 protein coding gene Chr7:123863755-123876341 (-)



Homology
more
  • Human Ortholog
    ZP2, zona pellucida glycoprotein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZP2, zona pellucida glycoprotein 2
  • Synonyms
    OOMD6, OZEMA6, Zp-2, ZPA
  • Links
    NCBI Gene ID: 7783
    neXtProt AC: NX_Q05996
    UniProt: Q05996

  • Chr Location
    16p12.3-p12.2; chr16:21197450-21214510 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female homozygous mutants exhibit a thin zona pellucida matrix in early ovarian follicles that becomes disassociated in pre-ovulatory follicles. Few oocytes are produced, and any that are fertilized fail to survive to the two-cell stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    11
  • cDNA Data
    32
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030911 Ensembl Gene Model | MGI Sequence Detail 18520 C57BL/6J ±  kb
    transcript ENSMUST00000033207 Ensembl | MGI Sequence Detail 2221 Not Applicable  
    polypeptide ENSMUSP00000033207 Ensembl | MGI Sequence Detail 713 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 3
      cDNA 33
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15968, MGD-MRK-15970
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 18
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:10307 Lunsford RD, et al., Genomic mapping of murine Zp-2 and Zp-3, two oocyte-specific loci encoding zona pellucida proteins. Genomics. 1990 Jan;6(1):184-7
    • Latest
      J:353355 Yao X, et al., BCAS2 regulates oocyte meiotic prophase I by participating in mRNA alternative splicing. FASEB J. 2024 Jan;38(1):e23361
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory