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Cdh4 Gene Detail
Summary
  • Symbol
    Cdh4
  • Name
    cadherin 4
  • Synonyms
    Rcad, R-Cadh, R-cadherin
  • Feature Type
    protein coding gene
  • IDs
    MGI:99218
    NCBI Gene: 12561
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179084228-179541166 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 101.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12768 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99218
 protein coding gene Chr2:179084224-179541166 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026980
 protein coding gene Chr2:185904091-186378593 (+)
A/J MGP_AJ_G0026946
 protein coding gene Chr2:178269406-178732066 (+)
AKR/J MGP_AKRJ_G0026916
 protein coding gene Chr2:183599778-184072361 (+)
BALB/cJ MGP_BALBcJ_G0026955
 protein coding gene Chr2:178737328-179196743 (+)
C3H/HeJ MGP_C3HHeJ_G0026696
 protein coding gene Chr2:183958206-184431650 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027401
 protein coding gene Chr2:191285928-191776407 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024768
 protein coding gene Chr2:168954405-169422684 (+)
CAST/EiJ MGP_CASTEiJ_G0026155
 protein coding gene Chr2:182189036-182731176 (+)
CBA/J MGP_CBAJ_G0026673
 protein coding gene Chr2:198222497-198708954 (+)
DBA/2J MGP_DBA2J_G0026811
 protein coding gene Chr2:177374307-177830123 (+)
FVB/NJ MGP_FVBNJ_G0026777
 protein coding gene Chr2:175963390-176428652 (+)
LP/J MGP_LPJ_G0026912
 protein coding gene Chr2:185888907-186371432 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026796
 protein coding gene Chr2:200886886-201372821 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027460
 protein coding gene Chr2:183564232-184037310 (+)
PWK/PhJ MGP_PWKPhJ_G0025891
 protein coding gene Chr2:174867888-175393539 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025691
 protein coding gene Chr2:180037271-180591912 (+)
WSB/EiJ MGP_WSBEiJ_G0026227
 protein coding gene Chr2:184537834-185009938 (+)



Homology
more
  • Human Ortholog
    CDH4, cadherin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDH4, cadherin 4
  • Synonyms
    CAD4, R-CAD, RCAD
  • Links
    NCBI Gene ID: 1002
    neXtProt AC: NX_P55283
    UniProt: P55283

  • Chr Location
    20q13.33; chr20:61252261-61940617 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in dilation of the proximal renal tubules and extensive vacuolization of tubule epithelium. Uretic bud epithelium appear disorganized and exhibit increased apoptosis at E15.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1363
  • Tissues
    427
  • cDNA Data
    50
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12561 NCBI Gene Model | MGI Sequence Detail 456939 C57BL/6J ±  kb
    transcript NM_001416935 RefSeq | MGI Sequence Detail 7442 ZRU/MplStud  
    polypeptide P39038 UniProt | EBI | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 51
      Primer pair 5
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15975, MGD-MRK-19361, MGI:2139310
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 60
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:2587 Moller CJ, et al., Differential expression of neural cell adhesion molecule and cadherins in pancreatic islets, glucagonomas, and insulinomas. Mol Endocrinol. 1992 Aug;6(8):1332-42
    • Latest
      J:349163 Huycke TR, et al., Patterning and folding of intestinal villi by active mesenchymal dewetting. Cell. 2024 Jun 6;187(12):3072-3089.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory