Etv2 MGI Mouse Gene Detail - MGI:99253

Symbol

Etv2
Name

ets variant 2
Synonyms

Etsrp71

Feature Type

protein coding gene
IDs

MGI:99253
NCBI Gene: 14008
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:30333041-30335277 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 18.92 cM, cytoband A3
Mapping Data

1 experiment

SNPs within 2kb

128 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99253	protein coding gene	Chr7:30333041-30335934 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032035	protein coding gene	Chr7:29646157-29648401 (-)
A/J	MGP_AJ_G0032012	protein coding gene	Chr7:28839632-28841911 (-)
AKR/J	MGP_AKRJ_G0031945	protein coding gene	Chr7:29572122-29574387 (-)
BALB/cJ	MGP_BALBcJ_G0032019	protein coding gene	Chr7:29029087-29031340 (-)
C3H/HeJ	MGP_C3HHeJ_G0031738	protein coding gene	Chr7:30035288-30037524 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032485	protein coding gene	Chr7:30607577-30609811 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029535	protein coding gene	Chr7:29867931-29870183 (-)
CAST/EiJ	MGP_CASTEiJ_G0031072	protein coding gene	Chr7:23289771-23292017 (-)
CBA/J	MGP_CBAJ_G0031704	protein coding gene	Chr7:32064004-32066240 (-)
DBA/2J	MGP_DBA2J_G0031856	protein coding gene	Chr7:28568555-28570824 (-)
FVB/NJ	MGP_FVBNJ_G0031813	protein coding gene	Chr7:28698953-28701187 (-)
LP/J	MGP_LPJ_G0031937	protein coding gene	Chr7:29950102-29952359 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031849	protein coding gene	Chr7:31301059-31303322 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032513	protein coding gene	Chr7:29084863-29087142 (-)
PWK/PhJ	MGP_PWKPhJ_G0030796	protein coding gene	Chr7:23608379-23610671 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030631	protein coding gene	Chr7:20095992-20098256 (-)
WSB/EiJ	MGP_WSBEiJ_G0031182	protein coding gene	Chr7:29472523-29474759 (-)

Human Ortholog

ETV2, ETS variant transcription factor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ETV2, ETS variant transcription factor 2
Synonyms

ER71, ETSRP71
Links

HGNC:3491

NCBI Gene ID: 2116

neXtProt AC: NX_O00321

UniProt: O00321
Chr Location

19q13.12; chr19:35641745-35644871 (+) GRCh38

MGI Vertebrate Homology

Etv2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ETV2
Gene Tree

Etv2

Diseases

1 with human ETV2 associations

				Human Disease	Mouse Models
				limb ischemia IDs limb ischemia DOID:0050852

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

44 phenotypes from 6 alleles in 11 genetic backgrounds
2 images
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

2
Targeted

11
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for null alleles die during organogenesis and lack blood vessels. In addition, mice homozygous for one allele lack endocardial cells, while mice homozygous for another allele lack blood cells.

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All GO Annotations

27
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

148
cDNA Data

7
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase etv2

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All Sequences

33
RefSeq

6
UniProt

2
CCDS

CCDS39888.1

Ensembl

ENSMUSG00000006311 (Evidence)
NCBI Gene

14008

			Length	Strain/Species	Flank
genomic	ENSMUSG00000006311	Ensembl Gene Model \| MGI Sequence Detail	2237	C57BL/6J	± kb
transcript	ENSMUST00000108147	Ensembl \| MGI Sequence Detail	1048	Not Applicable
polypeptide	ENSMUSP00000103782	Ensembl \| MGI Sequence Detail	335	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007224 ETS translocation variant 2

(term hierarchy)
InterPro Domains

IPR000418 Ets domain

IPR046328 ETS family

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 11

cDNA 7

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-16011

Summaries

All 74

Developmental Gene Expression 28

Gene Ontology 6

Phenotypes 30
Earliest

J:19172 Brown TA, et al., Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 1992 Dec;6(12B):2502-12
Latest

J:326952 Koyano-Nakagawa N, et al., Etv2 regulates enhancer chromatin status to initiate Shh expression in the limb bud. Nat Commun. 2022 Jul 21;13(1):4221

TSS for Etv2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71829	Chr7:30335939-30335954 (-)	-670 bp
Tssr71828	Chr7:30334172-30334197 (-)	1,092 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24