Eif3e MGI Mouse Gene Detail - MGI:99257 - eukaryotic translation initiation factor 3, subunit E

Symbol

Eif3e
Name

eukaryotic translation initiation factor 3, subunit E
Synonyms

48kDa, eIF3-p46, eIF3-p48, Eif3s6, Int6

Feature Type

protein coding gene
IDs

MGI:99257
NCBI Gene: 16341
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:43113454-43146115 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 16.73 cM
Mapping Data

7 experiments

SNPs within 2kb

945 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99257	protein coding gene	Chr15:43113436-43146132 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021825	protein coding gene	Chr15:41832975-41865605 (-)
A/J	MGP_AJ_G0021785	protein coding gene	Chr15:40228854-40261558 (-)
AKR/J	MGP_AKRJ_G0021766	protein coding gene	Chr15:41436646-41469346 (-)
BALB/cJ	MGP_BALBcJ_G0021792	protein coding gene	Chr15:40308062-40340756 (-)
C3H/HeJ	MGP_C3HHeJ_G0021566	protein coding gene	Chr15:41338361-41371059 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022231	protein coding gene	Chr15:43446742-43479438 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019768	protein coding gene	Chr15:37822398-37855372 (-)
CAST/EiJ	MGP_CASTEiJ_G0021083	protein coding gene	Chr15:41876068-41908823 (-)
CBA/J	MGP_CBAJ_G0021535	protein coding gene	Chr15:44954365-44991306 (-)
DBA/2J	MGP_DBA2J_G0021659	protein coding gene	Chr15:40061555-40094385 (-)
FVB/NJ	MGP_FVBNJ_G0021637	protein coding gene	Chr15:39380169-39412861 (-)
LP/J	MGP_LPJ_G0021729	protein coding gene	Chr15:41622246-41654876 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021661	protein coding gene	Chr15:48053912-48095063 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022254	protein coding gene	Chr15:41625318-41659817 (-)
PWK/PhJ	MGP_PWKPhJ_G0020828	protein coding gene	Chr15:40093814-40127493 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020665	protein coding gene	Chr15:41276387-41309640 (-)
WSB/EiJ	MGP_WSBEiJ_G0021138	protein coding gene	Chr15:41508128-41540859 (-)

Human Ortholog

EIF3E, eukaryotic translation initiation factor 3 subunit E

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF3E, eukaryotic translation initiation factor 3 subunit E
Synonyms

eIF3-p46, EIF3-P48, EIF3S6, INT6
Links

HGNC:3277

NCBI Gene ID: 3646

neXtProt AC: NX_P60228

UniProt: P60228
Chr Location

8q23.1; chr8:108162787-108443496 (-) GRCh38

MGI Vertebrate Homology

Eif3e stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF3E
Protein SuperFamily

eIF3e_su6
Gene Tree

Eif3e

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

15
Targeted

2
Genomic Mutations

2 involving Eif3e
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit prenatal lethality with reduced embryo size, cell size and fetal membranes. Mice heterozygous for a null allele exhibit reduced size, weight, MEF cell proliferation and MEF translation.

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

28
cDNA Data

19
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif3e

ZFIN eif3ea, eif3eb

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All Sequences

52
RefSeq

2
UniProt

4
CCDS

CCDS27452.1

Ensembl

ENSMUSG00000022336 (Evidence)
NCBI Gene

16341

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022336	Ensembl Gene Model \| MGI Sequence Detail	32662	C57BL/6J	± kb
transcript	ENSMUST00000022960	Ensembl \| MGI Sequence Detail	1506	Not Applicable
polypeptide	ENSMUSP00000022960	Ensembl \| MGI Sequence Detail	445	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006977 eukaryotic translation initiation factor 3 subunit E

(term hierarchy)
InterPro Domains

IPR016650 Eukaryotic translation initiation factor 3 subunit E

IPR019010 Eukaryotic translation initiation factor 3 subunit E, N-terminal

IPR000717 Proteasome component (PCI) domain

IPR036390 Winged helix DNA-binding domain superfamily
GlyGen

P60229 1 site, 1 O-linked glycan (1 site)

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All nucleic 29

Genomic 8

cDNA 20

Primer pair 1

Microarray probesets 4

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MGD-MRK-16016

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 9

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:314131 Fujii K, et al., Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Dev Cell. 2021 Nov 8;56(21):2928-2937.e9

TSS for Eif3e:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134190	Chr15:43146091-43146124 (-)	7 bp
Tssr134189	Chr15:43129174-43129190 (-)	16,933 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24