Matk MGI Mouse Gene Detail - MGI:99259 - megakaryocyte-associated tyrosine kinase

Symbol

Matk
Name

megakaryocyte-associated tyrosine kinase
Synonyms

CHK, Csk homologous kinase, HYL, Ntk

Feature Type

protein coding gene
IDs

MGI:99259
NCBI Gene: 17179
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:81088769-81098819 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

6 experiments

SNPs within 2kb

236 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99259	protein coding gene	Chr10:81088769-81099199 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017545	protein coding gene	Chr10:81956312-81970996 (+)
A/J	MGP_AJ_G0017523	protein coding gene	Chr10:79056076-79066970 (+)
AKR/J	MGP_AKRJ_G0017484	protein coding gene	Chr10:81229616-81240509 (+)
BALB/cJ	MGP_BALBcJ_G0017485	protein coding gene	Chr10:79275246-79285689 (+)
C3H/HeJ	MGP_C3HHeJ_G0017308	protein coding gene	Chr10:81323478-81334587 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017939	protein coding gene	Chr10:84773503-84784484 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015628	protein coding gene	Chr10:75254033-75263936 (+)
CAST/EiJ	MGP_CASTEiJ_G0016875	protein coding gene	Chr10:81554032-81564238 (+)
CBA/J	MGP_CBAJ_G0017280	protein coding gene	Chr10:88083067-88093564 (+)
DBA/2J	MGP_DBA2J_G0017386	protein coding gene	Chr10:78261391-78271847 (+)
FVB/NJ	MGP_FVBNJ_G0017380	protein coding gene	Chr10:77507225-77517900 (+)
LP/J	MGP_LPJ_G0017457	protein coding gene	Chr10:82410863-82421277 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017406	protein coding gene	Chr10:89933610-89945626 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017980	protein coding gene	Chr10:81233298-81246432 (+)
PWK/PhJ	MGP_PWKPhJ_G0016656	protein coding gene	Chr10:78153388-78164075 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016446	protein coding gene	Chr10:80180103-80190656 (+)
WSB/EiJ	MGP_WSBEiJ_G0016935	protein coding gene	Chr10:81262539-81274290 (+)

Human Ortholog

MATK, megakaryocyte-associated tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MATK, megakaryocyte-associated tyrosine kinase
Synonyms

CHK, CTK, HHYLTK, HYL, HYLTK, Lsk
Links

HGNC:6906

NCBI Gene ID: 4145

neXtProt AC: NX_P42679

UniProt: P42679
Chr Location

19p13.3; chr19:3777970-3802129 (-) GRCh38

MGI Vertebrate Homology

Matk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MATK
Gene Tree

Matk

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Matk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice are viable and fertile and appear normal. Unchallenged mutant mice exhibit no hematopoietic defects. SPKLS cell numbers are elevated. IL-7 induced BM cell proliferation and pre-B cell colony formation are enhanced. Antigen induced IFN-gamma secretion is reduced.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

13
cDNA Data

27
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN matk

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All Sequences

80
RefSeq

20
UniProt

8
CCDS

CCDS24048.1, CCDS70077.1, CCDS70078.1

Ensembl

ENSMUSG00000004933 (Evidence)
NCBI Gene

17179

			Length	Strain/Species	Flank
genomic	17179	NCBI Gene Model \| MGI Sequence Detail	10051	C57BL/6J	± kb
transcript	NM_010768	RefSeq \| MGI Sequence Detail	1997	C57BL/6
polypeptide	P41242	UniProt \| EBI \| MGI Sequence Detail	505	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000010204 megakaryocyte-associated tyrosine-protein kinase

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR035027 CSK-like, SH2 domain

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR051184 Tyrosine-phosphorylated adapter molecule

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

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All nucleic 37

Genomic 5

cDNA 31

Primer pair 1

Microarray probesets 4

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MGD-MRK-16018

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:289379 Nagy Z, et al., Interplay between the tyrosine kinases Chk and Csk and phosphatase PTPRJ is critical for regulating platelets in mice. Blood. 2020 Apr 30;135(18):1574-1587

TSS for Matk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94721	Chr10:81092890-81092894 (+)	4,123 bp
Tssr94722	Chr10:81093111-81093143 (+)	4,358 bp
Tssr94723	Chr10:81093150-81093167 (+)	4,390 bp
Tssr94724	Chr10:81093181-81093196 (+)	4,420 bp
Tssr94725	Chr10:81093290-81093360 (+)	4,556 bp
Tssr94726	Chr10:81093982-81094001 (+)	5,223 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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