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Prkci Gene Detail
Summary
  • Symbol
    Prkci
  • Name
    protein kinase C, iota
  • Synonyms
    2310021H13Rik, aPKClambda, Pkci, Pkcl, PKClambda, Prkcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:99260
    NCBI Gene: 18759
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:31049893-31106889 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 14.65 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1784 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99260
 protein coding gene Chr3:31049893-31107108 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027130
 protein coding gene Chr3:28509481-28571943 (+)
A/J MGP_AJ_G0027090
 protein coding gene Chr3:28137683-28194580 (+)
AKR/J MGP_AKRJ_G0027059
 protein coding gene Chr3:28570713-28628248 (+)
BALB/cJ MGP_BALBcJ_G0027102
 protein coding gene Chr3:27826629-27882914 (+)
C3H/HeJ MGP_C3HHeJ_G0026844
 protein coding gene Chr3:28581375-28639093 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027548
 protein coding gene Chr3:30019115-30079283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024909
 protein coding gene Chr3:26041047-26102579 (+)
CAST/EiJ MGP_CASTEiJ_G0026298
 protein coding gene Chr3:28507391-28565796 (+)
CBA/J MGP_CBAJ_G0026822
 protein coding gene Chr3:30778156-30840684 (+)
DBA/2J MGP_DBA2J_G0026956
 protein coding gene Chr3:27686763-27743213 (+)
FVB/NJ MGP_FVBNJ_G0026924
 protein coding gene Chr3:27132068-27188644 (+)
LP/J MGP_LPJ_G0027067
 protein coding gene Chr3:29204557-29267341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026944
 protein coding gene Chr3:33360770-33420616 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027607
 protein coding gene Chr3:28341532-28400576 (+)
PWK/PhJ MGP_PWKPhJ_G0026031
 protein coding gene Chr3:27204654-27263190 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025843
 protein coding gene Chr3:27843630-27900504 (+)
WSB/EiJ MGP_WSBEiJ_G0026372
 protein coding gene Chr3:28406189-28465535 (+)



Homology
more
  • Human Ortholog
    PRKCI, protein kinase C iota
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKCI, protein kinase C iota
  • Synonyms
    DXS1179E, nPKC-iota, PKCI
  • Links
    NCBI Gene ID: 5584
    neXtProt AC: NX_P41743
    UniProt: P41743

  • Chr Location
    3q26.2; chr3:170222424-170305977 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Prkci mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 7 alleles in 9 genetic backgrounds
    4 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete embryonic lethality. Muscle-specific deletion of this gene impairs glucose transport and induces metabolic and diabetic syndromes. Podocyte-specific deletion leads to altered podocyte architecture, proteinuria, and accelerated renal failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1067
  • Tissues
    159
  • cDNA Data
    19
  • Literature Summary
    98
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18759 NCBI Gene Model | MGI Sequence Detail 56997 C57BL/6J ±  kb
    transcript NM_008857 RefSeq | MGI Sequence Detail 4431 C57BL/6  
    polypeptide Q62074 UniProt | EBI | MGI Sequence Detail 595 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 20
      Primer pair 7
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16019, MGD-MRK-26062, MGI:104625, MGI:1919155, MGI:2139701
    References
    more
    • Summaries
      All 221
      Developmental Gene Expression 98
      Diseases 2
      Gene Ontology 23
      Phenotypes 62
    • Earliest
      J:17835 Akimoto K, et al., A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem. 1994 Apr 29;269(17):12677-83
    • Latest
      J:354796 Cho SH, et al., Perturbed cell cycle phase-dependent positioning and nuclear migration of retinal progenitors along the apico-basal axis underlie global retinal disorganization in the LCA8-like mouse model. Dev Biol. 2024 Sep 14;517:39-54
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory