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Adora2a Gene Detail
Summary
  • Symbol
    Adora2a
  • Name
    adenosine A2a receptor
  • Synonyms
    A2AAR, A2aR, A2a, Rs, AA2AR, ARA2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:99402
    NCBI Gene: 11540
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75152711-75170618 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.52 cM, cytoband B5.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99402
 protein coding gene Chr10:75152711-75170626 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017353
 protein coding gene Chr10:75473513-75493349 (+)
A/J MGP_AJ_G0017330
 protein coding gene Chr10:72880140-72897985 (+)
AKR/J MGP_AKRJ_G0017291
 protein coding gene Chr10:74830664-74848489 (+)
BALB/cJ MGP_BALBcJ_G0017290
 protein coding gene Chr10:73077734-73095564 (+)
C3H/HeJ MGP_C3HHeJ_G0017114
 protein coding gene Chr10:74873935-74891764 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017748
 protein coding gene Chr10:78146170-78164324 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015438
 protein coding gene Chr10:69348673-69366689 (+)
CAST/EiJ MGP_CASTEiJ_G0016684
 protein coding gene Chr10:75196720-75214270 (+)
CBA/J MGP_CBAJ_G0017086
 protein coding gene Chr10:81200778-81218623 (+)
DBA/2J MGP_DBA2J_G0017191
 protein coding gene Chr10:72183728-72201561 (+)
FVB/NJ MGP_FVBNJ_G0017184
 protein coding gene Chr10:71332689-71350604 (+)
LP/J MGP_LPJ_G0017264
 protein coding gene Chr10:75956217-75975891 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017212
 protein coding gene Chr10:83306749-83328959 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017787
 protein coding gene Chr10:74863643-74884242 (+)
PWK/PhJ MGP_PWKPhJ_G0016468
 protein coding gene Chr10:72007890-72025745 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016251
 protein coding gene Chr10:74113661-74131529 (+)
WSB/EiJ MGP_WSBEiJ_G0016748
 protein coding gene Chr10:74830697-74848499 (+)



Homology
more
  • Human Ortholog
    ADORA2A, adenosine A2a receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADORA2A, adenosine A2a receptor
  • Synonyms
    A2aR, ADORA2, RDC8
  • Links
    NCBI Gene ID: 135
    neXtProt AC: NX_P29274
    UniProt: P29274

  • Chr Location
    22q11.23; chr22:24417879-24442357 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Adora2a mouse models; 1 with human ADORA2A associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 5 alleles in 8 genetic backgrounds
    3 phenotypes from multigenic genotypes
    267 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are viable and fertile with reduced exploratory activity and displaying depressive rather than stimulatory response to caffeine. Mutants test more anxious, were more aggressive towards intruders, and slower to respond to pain stimuli. Blood pressure and heart rate are increased, as well as platelet aggregation rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    123
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    897
  • Tissues
    74
  • cDNA Data
    18
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020178 Ensembl Gene Model | MGI Sequence Detail 17908 C57BL/6J ±  kb
    transcript ENSMUST00000105420 Ensembl | MGI Sequence Detail 2596 Not Applicable  
    polypeptide ENSMUSP00000101060 Ensembl | MGI Sequence Detail 410 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 18
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16163
    References
    more
    • Summaries
      All 385
      Developmental Gene Expression 18
      Diseases 2
      Gene Ontology 20
      Phenotypes 267
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:353440 Nasrallah K, et al., Retrograde adenosine/A(2A) receptor signaling facilitates excitatory synaptic transmission and seizures. Cell Rep. 2024 Jul 23;43(7):114382
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory