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Nfe2l1 Gene Detail
Summary
  • Symbol
    Nfe2l1
  • Name
    nuclear factor, erythroid derived 2,-like 1
  • Synonyms
    Lcrf1, LCR-F1, NRF1, TCF-11, TCF11
  • Feature Type
    protein coding gene
  • IDs
    MGI:99421
    NCBI Gene: 18023
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96708240-96720794 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 60.12 cM, cytoband D-E
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99421
 protein coding gene Chr11:96708239-96720810 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019013
 protein coding gene Chr11:99171994-99184517 (-)
A/J MGP_AJ_G0018981
 protein coding gene Chr11:95107404-95119528 (-)
AKR/J MGP_AKRJ_G0018951
 protein coding gene Chr11:98057247-98069927 (-)
BALB/cJ MGP_BALBcJ_G0018954
 protein coding gene Chr11:95606504-95619095 (-)
C3H/HeJ MGP_C3HHeJ_G0018768
 protein coding gene Chr11:98181092-98193556 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019406
 protein coding gene Chr11:102250990-102263454 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017037
 protein coding gene Chr11:92587803-92600210 (-)
CAST/EiJ MGP_CASTEiJ_G0018321
 protein coding gene Chr11:99021045-99034732 (-)
CBA/J MGP_CBAJ_G0018739
 protein coding gene Chr11:106441089-106455546 (-)
DBA/2J MGP_DBA2J_G0018847
 protein coding gene Chr11:94667702-94682342 (-)
FVB/NJ MGP_FVBNJ_G0018836
 protein coding gene Chr11:94148476-94160955 (-)
LP/J MGP_LPJ_G0018917
 protein coding gene Chr11:99690994-99703456 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018863
 protein coding gene Chr11:106393158-106405689 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019446
 protein coding gene Chr11:98356926-98369098 (-)
PWK/PhJ MGP_PWKPhJ_G0018093
 protein coding gene Chr11:95638995-95652651 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017883
 protein coding gene Chr11:98088045-98101521 (-)
WSB/EiJ MGP_WSBEiJ_G0018371
 protein coding gene Chr11:98266932-98279510 (-)



Homology
more
  • Human Ortholog
    NFE2L1, NFE2 like bZIP transcription factor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFE2L1, NFE2 like bZIP transcription factor 1
  • Synonyms
    LCR-F1, NRF-1, NRF1, TCF11
  • Links
    NCBI Gene ID: 4779
    neXtProt AC: NX_Q14494
    UniProt: Q14494

  • Chr Location
    17q21.32; chr17:48048329-48061545 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Nfe2l1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 7 alleles in 9 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations fail to form a primitive streak, lack mesoderm, show a non-cell autonomous defect in definitive erythropoiesis, and die around embryonic day 7.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    913
  • Tissues
    99
  • cDNA Data
    258
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038615 Ensembl Gene Model | MGI Sequence Detail 12555 C57BL/6J ±  kb
    transcript ENSMUST00000107659 Ensembl | MGI Sequence Detail 2351 Not Applicable  
    polypeptide ENSMUSP00000103286 Ensembl | MGI Sequence Detail 742 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000011169 endoplasmic reticulum membrane sensor NFE2L1
      (term hierarchy)
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR004826 Basic leucine zipper domain, Maf-type
      IPR047167 Nuclear Factor Erythroid-derived 2-like
      IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
    • GlyGen
      Q61985 5 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 268
      Genomic 5
      cDNA 258
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16184, MGI:2143987, MGI:2144512
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 23
      Phenotypes 45
    • Earliest
      J:23248 McKie J, et al., Cloning and mapping of murine Nfe2l1. Genomics. 1995 Feb 10;25(3):716-9
    • Latest
      J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory