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Hira Gene Detail
Summary
  • Symbol
    Hira
  • Name
    histone cell cycle regulator
  • Synonyms
    D16Ertd95e, Gm15797, Tuple1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99430
    NCBI Gene: 15260
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18695787-18789059 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.69 cM, cytoband A-B1
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    94 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99430
 protein coding gene Chr16:18695500-18789059 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022623
 protein coding gene Chr16:16143454-16239844 (+)
A/J MGP_AJ_G0022584
 protein coding gene Chr16:15332342-15425760 (+)
AKR/J MGP_AKRJ_G0022561
 protein coding gene Chr16:15956991-16050594 (+)
BALB/cJ MGP_BALBcJ_G0022589
 protein coding gene Chr16:15491152-15589391 (+)
C3H/HeJ MGP_C3HHeJ_G0022356
 protein coding gene Chr16:16109858-16206886 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023038
 protein coding gene Chr16:16460465-16552917 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020558
 protein coding gene Chr16:15360463-16195513 (+)
CAST/EiJ MGP_CASTEiJ_G0021883
 protein coding gene Chr16:15994397-16094746 (+)
CBA/J MGP_CBAJ_G0022325
 protein coding gene Chr16:17137326-17232280 (+)
DBA/2J MGP_DBA2J_G0022457
 protein coding gene Chr16:15243989-15336770 (+)
FVB/NJ MGP_FVBNJ_G0022432
 protein coding gene Chr16:15307647-15408203 (+)
LP/J MGP_LPJ_G0022524
 protein coding gene Chr16:15895582-15991052 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022454
 protein coding gene Chr16:16778676-16880290 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023049
 protein coding gene Chr16:15873458-15967453 (+)
PWK/PhJ MGP_PWKPhJ_G0021625
 protein coding gene Chr16:15530604-15627898 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021453
 protein coding gene Chr16:15818986-15918646 (+)
WSB/EiJ MGP_WSBEiJ_G0021929
 protein coding gene Chr16:15896198-15989607 (+)



Homology
more
  • Human Ortholog
    HIRA, histone cell cycle regulator
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIRA, histone cell cycle regulator
  • Synonyms
    DGCR1, TUP1, TUPLE1
  • Links
    NCBI Gene ID: 7290
    neXtProt AC: NX_P54198
    UniProt: P54198

  • Chr Location
    22q11.21; chr22:19330698-19447450 (-)  GRCh38
Human Diseases
less
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    48 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit disrupted gastrulation, malformations of axial and paraxial mesoendoderm, abnormal placentas, failure of cardiac development, and lethality by embryonic day 11.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    947
  • Tissues
    84
  • cDNA Data
    27
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022702 Ensembl Gene Model | MGI Sequence Detail 93273 C57BL/6J ±  kb
    transcript ENSMUST00000004222 Ensembl | MGI Sequence Detail 4218 Not Applicable  
    polypeptide ENSMUSP00000004222 Ensembl | MGI Sequence Detail 1015 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 34
      cDNA 33
      Primer pair 13
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16194, MGI:1098613, MGI:1858444, MGI:2146730, MGI:3833679
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 16
      Diseases 4
      Gene Ontology 9
      Phenotypes 74
    • Earliest
      J:32846 Halford S, et al., Isolation of a putative transcriptional regulator from the region of 22q11 deleted in DiGeorge syndrome, Shprintzen syndrome and familial congenital heart disease. Hum Mol Genet. 1993 Dec;2(12):2099-107
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory