Arf1 MGI Mouse Gene Detail - MGI:99431

Symbol

Arf1
Name

ARF GTPase 1

Feature Type

protein coding gene
IDs

MGI:99431
NCBI Gene: 11840
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:59102237-59119042 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.05 cM, cytoband B2
Mapping Data

2 experiments

SNPs within 2kb

295 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99431	protein coding gene	Chr11:59102237-59119096 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018393	protein coding gene	Chr11:59028762-59045706 (-)
A/J	MGP_AJ_G0018362	protein coding gene	Chr11:56774961-56791673 (-)
AKR/J	MGP_AKRJ_G0018332	protein coding gene	Chr11:58674707-58692568 (-)
BALB/cJ	MGP_BALBcJ_G0018333	protein coding gene	Chr11:57127055-57144394 (-)
C3H/HeJ	MGP_C3HHeJ_G0018146	protein coding gene	Chr11:58553493-58570233 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018785	protein coding gene	Chr11:60903035-60922271 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016431	protein coding gene	Chr11:54025563-54042778 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0018120	protein coding gene	Chr11:63558387-63574810 (-)
DBA/2J	MGP_DBA2J_G0018229	protein coding gene	Chr11:56446127-56463552 (-)
FVB/NJ	MGP_FVBNJ_G0018220	protein coding gene	Chr11:56090683-56107533 (-)
LP/J	MGP_LPJ_G0018302	protein coding gene	Chr11:59628634-59647620 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018244	protein coding gene	Chr11:64705356-64706258 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018826	protein coding gene	Chr11:58696237-58713108 (-)
PWK/PhJ	MGP_PWKPhJ_G0017474	protein coding gene	Chr11:57026773-57044959 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023344	protein coding gene	Chr18:79936698-79939090 (+)
WSB/EiJ	MGP_WSBEiJ_G0017754	protein coding gene	Chr11:58381482-58382435 (-)

Human Ortholog

ARF1, ARF GTPase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARF1, ARF GTPase 1
Synonyms

PVNH8
Links

HGNC:652

NCBI Gene ID: 375

neXtProt AC: NX_P84077

UniProt: P84077
Chr Location

1q42.13; chr1:228082708-228099212 (+) GRCh38

MGI Vertebrate Homology

Arf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARF1
Gene Tree

Arf1

Diseases

1 with human ARF1 associations

				Human Disease	Mouse Models
				periventricular nodular heterotopia IDs periventricular nodular heterotopia DOID:0050454 MESH:D054091 OMIM:300049 OMIM:608097 OMIM:608098 OMIM:612881 OMIM:615544 ORDO:98892 UMLS_CUI:C1848213 UMLS_CUI:C1868720

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Gene trapped

22
Targeted

6
Genomic Mutations

1 involving Arf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Homozygous embryos die in utero shortly after implantation.

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All GO Annotations

64
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

85
cDNA Data

35
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ARF1

Xenbase arf3

ZFIN arf1

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All Sequences

72
RefSeq

4
UniProt

1
CCDS

CCDS24765.1

Ensembl

ENSMUSG00000048076 (Evidence)
NCBI Gene

11840

			Length	Strain/Species	Flank
genomic	11840	NCBI Gene Model \| MGI Sequence Detail	16806	C57BL/6J	± kb
transcript	NM_001130408	RefSeq \| MGI Sequence Detail	2046	C57BL/6
polypeptide	P84078	UniProt \| EBI \| MGI Sequence Detail	181	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004201 ADP-ribosylation factor 1

(term hierarchy)
PDB

1O3Y, 2J59
EC

3.6.5.2
InterPro Domains

IPR045872 ADP-ribosylation factor 1-5

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain
GlyGen

P84078 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

cDNA 36

Primer pair 1

Microarray probesets 6

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MGD-MRK-16195

Summaries

All 62

Developmental Gene Expression 6

Gene Ontology 14

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:346136 Matsuki T, et al., Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Mol Biol Rep. 2024 Jan 16;51(1):106

TSS for Arf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr108215	Chr11:59119034-59119073 (-)	-12 bp
Tssr108214	Chr11:59118705-59118756 (-)	311 bp
Tssr108213	Chr11:59103492-59103514 (-)	15,539 bp
Tssr108212	Chr11:59103337-59103361 (-)	15,693 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24