Arf3 MGI Mouse Gene Detail - MGI:99432

Symbol

Arf3
Name

ARF GTPase 3
Synonyms

5430400P17Rik

Feature Type

protein coding gene
IDs

MGI:99432
NCBI Gene: 11842
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:98635505-98660999 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 54.65 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

663 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99432	protein coding gene	Chr15:98634515-98661095 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022309	protein coding gene	Chr15:100490806-100518905 (-)
A/J	MGP_AJ_G0022267	protein coding gene	Chr15:96525700-96551157 (-)
AKR/J	MGP_AKRJ_G0022242	protein coding gene	Chr15:99499181-99524557 (-)
BALB/cJ	MGP_BALBcJ_G0022274	protein coding gene	Chr15:96718537-96744166 (-)
C3H/HeJ	MGP_C3HHeJ_G0022042	protein coding gene	Chr15:99545433-99572892 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022719	protein coding gene	Chr15:104213746-104255448 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020244	protein coding gene	Chr15:92441767-92468469 (-)
CAST/EiJ	MGP_CASTEiJ_G0021565	protein coding gene	Chr15:100389527-100418991 (-)
CBA/J	MGP_CBAJ_G0022011	protein coding gene	Chr15:107752285-107785993 (-)
DBA/2J	MGP_DBA2J_G0022137	protein coding gene	Chr15:95967969-95993480 (-)
FVB/NJ	MGP_FVBNJ_G0022117	protein coding gene	Chr15:94946330-94972537 (-)
LP/J	MGP_LPJ_G0022209	protein coding gene	Chr15:100641165-100669683 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022137	protein coding gene	Chr15:111768073-111794345 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022734	protein coding gene	Chr15:99577926-99604230 (-)
PWK/PhJ	MGP_PWKPhJ_G0021306	protein coding gene	Chr15:96086783-96113347 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021141	protein coding gene	Chr15:99423829-99450330 (-)
WSB/EiJ	MGP_WSBEiJ_G0021615	protein coding gene	Chr15:100122470-100150130 (-)

Human Ortholog

ARF3, ARF GTPase 3

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARF3, ARF GTPase 3
Links

HGNC:654

NCBI Gene ID: 377

neXtProt AC: NX_P61204

UniProt: P61204
Chr Location

12q13.12; chr12:48935723-48957487 (-) GRCh38

MGI Vertebrate Homology

Arf3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ARF3
Gene Tree

Arf3

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

1
Gene trapped

9
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Arf3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

841
Tissues

123
cDNA Data

232
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arf3

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All Sequences

49
RefSeq

4
UniProt

4
CCDS

CCDS27804.1

Ensembl

ENSMUSG00000051853 (Evidence)
NCBI Gene

11842

			Length	Strain/Species	Flank
genomic	11842	NCBI Gene Model \| MGI Sequence Detail	25495	C57BL/6J	± kb
transcript	NM_001355510	RefSeq \| MGI Sequence Detail	3612	C57BL/6
polypeptide	P61205	UniProt \| EBI \| MGI Sequence Detail	181	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000004202 ADP-ribosylation factor 3

(term hierarchy)
InterPro Domains

IPR045872 ADP-ribosylation factor 1-5

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR006689 Small GTPase superfamily, ARF/SAR type

IPR024156 Small GTPase superfamily, ARF type

IPR005225 Small GTP-binding protein domain
GlyGen

P61205 1 site, 1 O-linked glycan (1 site)

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All nucleic 234

cDNA 232

Primer pair 1

Other 1

Microarray probesets 6

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MGD-MRK-16196, MGI:1926013, MGI:2146098

Summaries

All 64

Developmental Gene Expression 3

Diseases 1

Gene Ontology 6

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:346136 Matsuki T, et al., Expression analysis of type I ARF small GTPases ARF1-3 during mouse brain development. Mol Biol Rep. 2024 Jan 16;51(1):106

TSS for Arf3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136282	Chr15:98661108-98661119 (-)	-115 bp
Tssr136281	Chr15:98661076-98661101 (-)	-90 bp
Tssr136280	Chr15:98661017-98661071 (-)	-45 bp
Tssr136278	Chr15:98640526-98640542 (-)	20,465 bp
Tssr136277	Chr15:98640492-98640506 (-)	20,500 bp
Tssr136276	Chr15:98639256-98639268 (-)	21,737 bp
Tssr136275	Chr15:98638247-98638295 (-)	22,728 bp
Tssr136274	Chr15:98638121-98638232 (-)	22,822 bp
Tssr136273	Chr15:98638035-98638065 (-)	22,949 bp
Tssr136272	Chr15:98636599-98636666 (-)	24,366 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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