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Arf5 Gene Detail
Summary
  • Symbol
    Arf5
  • Name
    ARF GTPase 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:99434
    NCBI Gene: 11844
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:28423603-28426601 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    126 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99434
 protein coding gene Chr6:28423559-28426601 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030508
 protein coding gene Chr6:26150875-26153849 (+)
A/J MGP_AJ_G0030481
 protein coding gene Chr6:25045339-25048381 (+)
AKR/J MGP_AKRJ_G0030408
 protein coding gene Chr6:25873503-25876544 (+)
BALB/cJ MGP_BALBcJ_G0030491
 protein coding gene Chr6:25209281-25212323 (+)
C3H/HeJ MGP_C3HHeJ_G0030204
 protein coding gene Chr6:25858191-25861140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030945
 protein coding gene Chr6:26946457-26951067 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028156
 protein coding gene Chr6:23276151-23279105 (+)
CAST/EiJ MGP_CASTEiJ_G0029606
 protein coding gene Chr6:25666085-25669286 (+)
CBA/J MGP_CBAJ_G0030182
 protein coding gene Chr6:27913346-27916288 (+)
DBA/2J MGP_DBA2J_G0030326
 protein coding gene Chr6:25001015-25004059 (+)
FVB/NJ MGP_FVBNJ_G0030280
 protein coding gene Chr6:24752907-24755944 (+)
LP/J MGP_LPJ_G0030413
 protein coding gene Chr6:26284522-26287470 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030316
 protein coding gene Chr6:30470011-30473114 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030975
 protein coding gene Chr6:25752268-25755309 (+)
PWK/PhJ MGP_PWKPhJ_G0029320
 protein coding gene Chr6:24527742-24532494 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029156
 protein coding gene Chr6:25447969-25450899 (+)
WSB/EiJ MGP_WSBEiJ_G0029682
 protein coding gene Chr6:25720430-25723420 (+)



Homology
more
  • Human Ortholog
    ARF5, ARF GTPase 5
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARF5, ARF GTPase 5
  • Links
    NCBI Gene ID: 381
    neXtProt AC: NX_P84085
    UniProt: P84085

  • Chr Location
    7q32.1; chr7:127588386-127591700 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    4 phenotype references
Mice homozygous for a null allele exhibit no abnormalities. Mice also heterozygous for an arf4 null allele exhibit impaired coordination, tremors and altered brain wave pattern and Purkinje cell electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    4
  • cDNA Data
    23
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11844 NCBI Gene Model | MGI Sequence Detail 2999 C57BL/6J ±  kb
transcript NM_007480 RefSeq | MGI Sequence Detail 1089 C57BL/6  
polypeptide P84084 UniProt | EBI | MGI Sequence Detail 180 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16198
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 4
  • Earliest
    J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
  • Latest
    J:342331 Hara Y, et al., ADP Ribosylation Factor 4 (Arf4) Regulates Radial Migration through N-Cadherin Trafficking during Cerebral Cortical Development. eNeuro. 2023 Nov;10(11):ENEURO.0125-23.2023
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory