Ifi47 MGI Mouse Gene Detail - MGI:99448 - interferon gamma inducible protein 47

Symbol

Ifi47
Name

interferon gamma inducible protein 47
Synonyms

47kDa, Igrd, Iigp4, IRG-47

Feature Type

protein coding gene
IDs

MGI:99448
NCBI Gene: 15953
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr11:48967414-48987801 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 29.08 cM, cytoband B1.2
Mapping Data

1 experiment

SNPs within 2kb

139 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99448	protein coding gene	Chr11:48967414-48987814 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018216	protein coding gene	Chr11:48140936-48152214 (+)
A/J	MGP_AJ_G0018186	protein coding gene	Chr11:46280270-46300566 (+)
AKR/J	MGP_AKRJ_G0018153	protein coding gene	Chr11:47727138-47745649 (+)
BALB/cJ	MGP_BALBcJ_G0018155	protein coding gene	Chr11:46532308-46552847 (+)
C3H/HeJ	MGP_C3HHeJ_G0017969	protein coding gene	Chr11:47750343-47773667 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018606	protein coding gene	Chr11:49583763-49605559 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016261	protein coding gene	Chr11:43999102-44009293 (+)
CAST/EiJ	MGP_CASTEiJ_G0017532	protein coding gene	Chr11:47809693-47823404 (+)
CBA/J	MGP_CBAJ_G0017941	protein coding gene	Chr11:51894546-51918723 (+)
DBA/2J	MGP_DBA2J_G0018050	protein coding gene	Chr11:46138542-46158536 (+)
FVB/NJ	MGP_FVBNJ_G0018045	protein coding gene	Chr11:45732853-45753023 (+)
LP/J	MGP_LPJ_G0018124	protein coding gene	Chr11:48464914-48475026 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018069	protein coding gene	Chr11:53413451-53434412 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018644	protein coding gene	Chr11:47654365-47876584 (+)
PWK/PhJ	MGP_PWKPhJ_G0017311	protein coding gene	Chr11:46476551-46487427 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017105	protein coding gene	Chr11:47543811-47554980 (+)
WSB/EiJ	MGP_WSBEiJ_G0017583	protein coding gene	Chr11:47518710-47528885 (+)

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MGI Vertebrate Homology

Ifi47 stringent orthology
1 mouse;1 rat;3 zebrafish
Gene Tree

Ifi47

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Ifi47
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

In the absence of infection, mice show no overt phenotype. Resistance to protozoan parasitic infection is impaired in homozygous mutant mice, whereas resistance to bacterial and viral infection are normal.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

826
Tissues

97
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

6
UniProt

5
CCDS

CCDS24595.1

Ensembl

ENSMUSG00000078920 (Evidence)
NCBI Gene

15953

			Length	Strain/Species	Flank
genomic	ENSMUSG00000078920	Ensembl Gene Model \| MGI Sequence Detail	20388	C57BL/6J	± kb
transcript	ENSMUST00000109202	Ensembl \| MGI Sequence Detail	1773	Not Applicable
polypeptide	ENSMUSP00000104825	Ensembl \| MGI Sequence Detail	420	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR051515 Immunity-related GTPase

IPR007743 Immunity-related GTPases-like

IPR030385 IRG-type guanine nucleotide-binding (G) domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 10

Genomic 1

cDNA 8

Primer pair 1

Microarray probesets 3

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MGD-MRK-16217

Summaries

All 30

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 9
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:307941 Zuo B, et al., Analysis of microsatellite polymorphism in inbred knockout mice. PLoS One. 2012;7(4):e34555

TSS for Ifi47:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101159	Chr11:48967379-48967404 (+)	-22 bp
Tssr101160	Chr11:48967411-48967428 (+)	6 bp
Tssr101161	Chr11:48977499-48977504 (+)	10,088 bp
Tssr101162	Chr11:48977598-48977633 (+)	10,202 bp
Tssr101163	Chr11:48977634-48977665 (+)	10,236 bp
Tssr101164	Chr11:48977804-48977811 (+)	10,394 bp
Tssr101165	Chr11:48977849-48977879 (+)	10,450 bp
Tssr101166	Chr11:48977888-48977899 (+)	10,480 bp
Tssr101167	Chr11:48979550-48979554 (+)	12,138 bp
Tssr101168	Chr11:48979733-48979740 (+)	12,323 bp
Tssr101169	Chr11:48980410-48980432 (+)	13,007 bp
Tssr101170	Chr11:48981006-48981039 (+)	13,609 bp
Tssr101171	Chr11:48983777-48983782 (+)	16,366 bp
Tssr101172	Chr11:48986678-48986692 (+)	19,271 bp
Tssr101173	Chr11:48987533-48987562 (+)	20,134 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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