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Nr3c2 Gene Detail
Summary
  • Symbol
    Nr3c2
  • Name
    nuclear receptor subfamily 3, group C, member 2
  • Synonyms
    aldosterone receptor, mineralocorticoid receptor, Mlr, MR
  • Feature Type
    protein coding gene
  • IDs
    MGI:99459
    NCBI Gene: 110784
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:77626422-77971641 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 36.34 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9359 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99459
 protein coding gene Chr8:77626070-77971641 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033799
 protein coding gene Chr8:77453044-77818130 (+)
A/J MGP_AJ_G0033781
 protein coding gene Chr8:74362595-74705806 (+)
AKR/J MGP_AKRJ_G0033708
 protein coding gene Chr8:76592351-76937783 (+)
BALB/cJ MGP_BALBcJ_G0033775
 protein coding gene Chr8:74462166-74814890 (+)
C3H/HeJ MGP_C3HHeJ_G0033484
 protein coding gene Chr8:77199451-77554674 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034295
 protein coding gene Chr8:80427831-80801758 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031236
 protein coding gene Chr8:68466038-68807888 (+)
CAST/EiJ MGP_CASTEiJ_G0032814
 protein coding gene Chr8:76504803-76873348 (+)
CBA/J MGP_CBAJ_G0033463
 protein coding gene Chr8:83242189-83640634 (+)
DBA/2J MGP_DBA2J_G0033617
 protein coding gene Chr8:74072093-74420627 (+)
FVB/NJ MGP_FVBNJ_G0033562
 protein coding gene Chr8:73073156-73418000 (+)
LP/J MGP_LPJ_G0033706
 protein coding gene Chr8:77498616-77867989 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033605
 protein coding gene Chr8:85932441-86301181 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034312
 protein coding gene Chr8:76602833-76958370 (+)
PWK/PhJ MGP_PWKPhJ_G0032519
 protein coding gene Chr8:73296381-73657364 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032357
 protein coding gene Chr8:75445057-75793133 (+)
WSB/EiJ MGP_WSBEiJ_G0032928
 protein coding gene Chr8:76923954-77282994 (+)



Homology
more
  • Human Ortholog
    NR3C2, nuclear receptor subfamily 3 group C member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR3C2, nuclear receptor subfamily 3 group C member 2
  • Synonyms
    MCR, MLR, MR, NR3C2VIT
  • Links
    NCBI Gene ID: 4306
    neXtProt AC: NX_P08235
    UniProt: P08235

  • Chr Location
    4q31.23; chr4:148078762-148445508 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nr3c2 mouse models; 2 with human NR3C2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 6 alleles in 7 genetic backgrounds
    1 images
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit weight loss and symptoms of pseudohypoaldosteronism, and eventually die at around day 10 after birth from renal salt wasting and dehydration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    74
  • cDNA Data
    8
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110784 NCBI Gene Model | MGI Sequence Detail 345220 C57BL/6J ±  kb
    transcript NM_001426577 RefSeq | MGI Sequence Detail 5925 C57BL/6  
    polypeptide Q8VII8 UniProt | EBI | MGI Sequence Detail 978 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 36
      cDNA 9
      Primer pair 4
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-16228
    References
    more
    • Summaries
      All 174
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 11
      Phenotypes 82
    • Earliest
      J:21847 Terajima M, et al., Structural organization of the mouse glycophorin A gene. J Biochem. 1994 Nov;116(5):1105-10
    • Latest
      J:348366 Gomatam CK, et al., Cell-type specific effects of mineralocorticoid receptor gene expression suggest intercellular communication regulating fibrosis in skeletal muscle disease. Front Physiol. 2024;15:1322729
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory