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F11 Gene Detail
Summary
  • Symbol
    F11
  • Name
    coagulation factor XI
  • Synonyms
    1600027G01Rik, Cf11, FXI, plasma thromboplastin antecedent
  • Feature Type
    protein coding gene
  • IDs
    MGI:99481
    NCBI Gene: 109821
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45694211-45715068 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 25.14 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    907 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99481
 protein coding gene Chr8:45693696-45715092 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033572
 protein coding gene Chr8:44269616-44291019 (-)
A/J MGP_AJ_G0033554
 protein coding gene Chr8:42581453-42600932 (-)
AKR/J MGP_AKRJ_G0033479
 protein coding gene Chr8:43821723-43841068 (-)
BALB/cJ MGP_BALBcJ_G0033551
 protein coding gene Chr8:42749268-42769484 (-)
C3H/HeJ MGP_C3HHeJ_G0033260
 protein coding gene Chr8:44345609-44365918 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034067
 protein coding gene Chr8:45957822-45982828 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031016
 protein coding gene Chr8:38880250-38901498 (-)
CAST/EiJ MGP_CASTEiJ_G0032586
 protein coding gene Chr8:43761756-43781691 (-)
CBA/J MGP_CBAJ_G0033239
 protein coding gene Chr8:47808363-47832160 (-)
DBA/2J MGP_DBA2J_G0033392
 protein coding gene Chr8:42389927-42410223 (-)
FVB/NJ MGP_FVBNJ_G0033333
 protein coding gene Chr8:41886808-41908121 (-)
LP/J MGP_LPJ_G0033480
 protein coding gene Chr8:44288648-44312277 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033378
 protein coding gene Chr8:47891059-47912964 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034085
 protein coding gene Chr8:43985395-44007370 (-)
PWK/PhJ MGP_PWKPhJ_G0032294
 protein coding gene Chr8:41918170-41940566 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032130
 protein coding gene Chr8:43154753-43176582 (-)
WSB/EiJ MGP_WSBEiJ_G0032702
 protein coding gene Chr8:44232832-44254668 (-)



Homology
more
  • Human Ortholog
    F11, coagulation factor XI
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F11, coagulation factor XI
  • Synonyms
    FXI, PTA
  • Links
    NCBI Gene ID: 2160
    neXtProt AC: NX_P03951
    UniProt: P03951

  • Chr Location
    4q35.2; chr4:186266189-186289681 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with F11 mouse models; 2 with human F11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    38 phenotypes from multigenic genotypes
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show a tendency for slightly prolonged tail transection bleeding times and are protected from vessel-occluding fibrin formation after transient ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    732
  • Tissues
    4
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031645 Ensembl Gene Model | MGI Sequence Detail 20858 C57BL/6J ±  kb
transcript ENSMUST00000034064 Ensembl | MGI Sequence Detail 2240 Not Applicable  
polypeptide ENSMUSP00000034064 Ensembl | MGI Sequence Detail 624 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 1
    cDNA 16
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16255, MGI:1919281, MGI:2142579
References
more
  • Summaries
    All 61
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 27
  • Earliest
    J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory