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Chuk Gene Detail
Summary
  • Symbol
    Chuk
  • Name
    conserved helix-loop-helix ubiquitous kinase
  • Synonyms
    Chuk1, IkappaB kinase alpha, IKK 1, IKK-1, IKK1, IKK[a], IKK alpha, IKK-alpha, IKKalpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:99484
    NCBI Gene: 12675
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:44061774-44095919 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.71 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    914 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99484
 protein coding gene Chr19:44061773-44095940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025163
 protein coding gene Chr19:43525347-43559719 (-)
A/J MGP_AJ_G0025140
 protein coding gene Chr19:41446992-41481805 (-)
AKR/J MGP_AKRJ_G0025108
 protein coding gene Chr19:42758428-42792556 (-)
BALB/cJ MGP_BALBcJ_G0025134
 protein coding gene Chr19:41492334-41526987 (-)
C3H/HeJ MGP_C3HHeJ_G0024894
 protein coding gene Chr19:42933268-42969016 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025577
 protein coding gene Chr19:44589896-44626129 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022991
 protein coding gene Chr19:40739269-40773266 (-)
CAST/EiJ MGP_CASTEiJ_G0024359
 protein coding gene Chr19:42644514-42681609 (-)
CBA/J MGP_CBAJ_G0024874
 protein coding gene Chr19:46811150-46849713 (-)
DBA/2J MGP_DBA2J_G0025006
 protein coding gene Chr19:41272970-41306640 (-)
FVB/NJ MGP_FVBNJ_G0024967
 protein coding gene Chr19:41033727-41069329 (-)
LP/J MGP_LPJ_G0025092
 protein coding gene Chr19:43484499-43518454 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024998
 protein coding gene Chr19:46325923-46362370 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025635
 protein coding gene Chr19:42847965-42884314 (-)
PWK/PhJ MGP_PWKPhJ_G0024108
 protein coding gene Chr19:41173774-41208771 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023912
 protein coding gene Chr19:41560081-41596843 (-)
WSB/EiJ MGP_WSBEiJ_G0024429
 protein coding gene Chr19:42987405-43022259 (-)



Homology
more
  • Human Ortholog
    CHUK, component of inhibitor of nuclear factor kappa B kinase complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHUK, component of inhibitor of nuclear factor kappa B kinase complex
  • Synonyms
    BPS2, IKBKA, IKK-1, IKK1, IKKA, IKK-alpha, NFKBIKA, TCF16
  • Links
    NCBI Gene ID: 1147
    neXtProt AC: NX_O15111
    UniProt: O15111

  • Chr Location
    10q24.31; chr10:100186319-100229596 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Chuk mouse models; 3 with human CHUK associations

Human Disease Mouse Models
      
IDs
 View 3 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    146 phenotypes from 10 alleles in 18 genetic backgrounds
    56 phenotypes from multigenic genotypes
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die neonataly and exhibit thickened, taut, adhesive skin that prevents appendages from protruding from the trunk, absence of whiskers, skeletal abnormalities, and closed esophagus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    73
  • cDNA Data
    105
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025199 Ensembl Gene Model | MGI Sequence Detail 34146 C57BL/6J ±  kb
    transcript ENSMUST00000026217 Ensembl | MGI Sequence Detail 3502 Not Applicable  
    polypeptide ENSMUSP00000026217 Ensembl | MGI Sequence Detail 745 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      cDNA 108
      Primer pair 4
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16258, MGI:2147493
    References
    more
    • Summaries
      All 251
      Developmental Gene Expression 27
      Diseases 1
      Gene Ontology 32
      Phenotypes 107
    • Earliest
      J:26193 Mock BA, et al., CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19. Genomics. 1995 May 20;27(2):348-51
    • Latest
      J:358459 Huang W, et al., Ulinastatin attenuates renal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-triggered pyroptosis. Int Immunopharmacol. 2024 Dec 25;143(Pt 1):113306
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory