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Brd2 Gene Detail
Summary
  • Symbol
    Brd2
  • Name
    bromodomain containing 2
  • Synonyms
    D17H6S113E, Frg-1, Fsrg1, Ring3, Rnf3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99495
    NCBI Gene: 14312
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34330993-34341581 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM, cytoband D
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99495
 protein coding gene Chr17:34330993-34341608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023557
 protein coding gene Chr17:34089600-34100217 (-)
A/J MGP_AJ_G0023521
 protein coding gene Chr17:32904382-32914976 (-)
AKR/J MGP_AKRJ_G0023484
 protein coding gene Chr17:33320693-33331287 (-)
BALB/cJ MGP_BALBcJ_G0023523
 protein coding gene Chr17:33079115-33089710 (-)
C3H/HeJ MGP_C3HHeJ_G0023284
 protein coding gene Chr17:33677238-33687906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023964
 protein coding gene Chr17:35392963-35403561 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021442
 protein coding gene Chr17:30444494-30455128 (-)
CAST/EiJ MGP_CASTEiJ_G0022783
 protein coding gene Chr17:33776850-33787450 (-)
CBA/J MGP_CBAJ_G0023261
 protein coding gene Chr17:36794145-36804739 (-)
DBA/2J MGP_DBA2J_G0023392
 protein coding gene Chr17:32289168-32299763 (-)
FVB/NJ MGP_FVBNJ_G0023356
 protein coding gene Chr17:32156794-32168221 (-)
LP/J MGP_LPJ_G0023467
 protein coding gene Chr17:34365303-34375912 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023379
 protein coding gene Chr17:35829932-35840527 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024006
 protein coding gene Chr17:33671901-33682494 (-)
PWK/PhJ MGP_PWKPhJ_G0022533
 protein coding gene Chr17:31216770-31227430 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022348
 protein coding gene Chr17:31621138-31631698 (-)
WSB/EiJ MGP_WSBEiJ_G0022844
 protein coding gene Chr17:33685100-33695702 (-)



Homology
more
  • Human Ortholog
    BRD2, bromodomain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BRD2, bromodomain containing 2
  • Synonyms
    BRD2-IT1, D6S113E, FSH, FSHRG1, FSRG1, NAT, O27.1.1, RING3, RNF3
  • Links
    NCBI Gene ID: 6046
    neXtProt AC: NX_P25440
    UniProt: P25440

  • Chr Location
    6p21.32; chr6:32968594-32981505 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human BRD2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    129 phenotypes from 6 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with decreased embryo size, decreased cell proliferation, a delay in the cell cycle, and increased cell death. Heterozygous mice also display decreased cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    99
  • cDNA Data
    26
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14312 NCBI Gene Model | MGI Sequence Detail 10589 C57BL/6J ±  kb
    transcript NM_001204973 RefSeq | MGI Sequence Detail 4685 ZRU/MplStud  
    polypeptide Q7JJ13 UniProt | EBI | MGI Sequence Detail 798 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 9
      cDNA 28
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16269, MGI:2147056
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 16
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:17944 Hanson IM, et al., Colinearity of novel genes in the class II regions of the MHC in mouse and human. Immunogenetics. 1991;34(1):5-11
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory