Tmsb4x MGI Mouse Gene Detail - MGI:99510 - thymosin, beta 4, X chromosome

Symbol

Tmsb4x
Name

thymosin, beta 4, X chromosome
Synonyms

Ptmb4, Tb4, Tbeta4

Feature Type

protein coding gene
IDs

MGI:99510
NCBI Gene: 19241
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

ChrX:165990089-165992311 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 78.28 cM
Mapping Data

6 experiments

SNPs within 2kb

92 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99510	protein coding gene	ChrX:165990089-165996475 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0036269	protein coding gene	ChrX:165373722-165375943 (-)
A/J	MGP_AJ_G0036238	protein coding gene	ChrX:164522905-164525126 (-)
AKR/J	MGP_AKRJ_G0036168	protein coding gene	ChrX:169803900-169806121 (-)
BALB/cJ	MGP_BALBcJ_G0036233	protein coding gene	ChrX:162469464-162471685 (-)
C3H/HeJ	MGP_C3HHeJ_G0035940	protein coding gene	ChrX:165678486-165680707 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036756	protein coding gene	ChrX:170173116-170176480 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033576	protein coding gene	ChrX:155340147-155342387 (-)
CAST/EiJ	MGP_CASTEiJ_G0035227	protein coding gene	ChrX:144569964-144572186 (-)
CBA/J	MGP_CBAJ_G0035914	protein coding gene	ChrX:175143452-175145673 (-)
DBA/2J	MGP_DBA2J_G0036080	protein coding gene	ChrX:163327053-163329274 (-)
FVB/NJ	MGP_FVBNJ_G0036012	protein coding gene	ChrX:162461661-162463882 (-)
LP/J	MGP_LPJ_G0036165	protein coding gene	ChrX:166462011-166464232 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0036044	protein coding gene	ChrX:183832426-183834645 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036795	protein coding gene	ChrX:164836468-164838687 (-)
PWK/PhJ	MGP_PWKPhJ_G0034926	protein coding gene	ChrX:141303783-141306000 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034745	protein coding gene	ChrX:145112769-145115009 (-)
WSB/EiJ	MGP_WSBEiJ_G0035363	protein coding gene	ChrX:162683492-162685711 (-)

Human Ortholog

TMSB4X, thymosin beta 4 X-linked

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMSB4X, thymosin beta 4 X-linked
Synonyms

FX, PTMB4, TB4X, TMSB4
Links

HGNC:11881

NCBI Gene ID: 7114

neXtProt AC: NX_P62328

UniProt: P62328
Chr Location

Xp22.2; chrX:12975110-12977227 (+) GRCh38

Human Ortholog

TMSB4Y, thymosin beta 4 Y-linked
Synonyms

TB4Y
Links

HGNC:11882

NCBI Gene ID: 9087

neXtProt AC: NX_O14604

UniProt: O14604
Chr Location

Yq11.221; chrY:13703899-13706024 (+) GRCh38

MGI Vertebrate Homology

Tmsb4x stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMSB4X, TMSB4Y
Protein SuperFamily

Thymosin_beta
Gene Tree

Tmsb4x

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Phenotype Summary

18 phenotypes from 5 alleles in 3 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

3
Gene trapped

5
Targeted

8
Genomic Mutations

1 involving Tmsb4x
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele are viable and fertile with no notable cardiovascular defects in adult mice. Mice homozygous for a different allele exhibit partial embryonic lethality due to vascular defects associated with impaired differentiationof mural cells from mesoderm in some mice.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

917
Tissues

157
cDNA Data

20
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmsb4x

ZFIN tmsb4x

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS30529.1

Ensembl

ENSMUSG00000049775 (Evidence)
NCBI Gene

19241

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049775	Ensembl Gene Model \| MGI Sequence Detail	2223	C57BL/6J	± kb
transcript	ENSMUST00000112176	Ensembl \| MGI Sequence Detail	698	Not Applicable
polypeptide	ENSMUSP00000107798	Ensembl \| MGI Sequence Detail	50	Not Applicable

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UniProt

2 Sequences
PDB

1T44, 3M3N
InterPro Domains

IPR001152 Beta-thymosin

IPR038386 Beta-thymosin superfamily

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All nucleic 31

Genomic 2

cDNA 21

Primer pair 6

Other 2

Microarray probesets 3

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MGD-MRK-16287

Summaries

All 96

Developmental Gene Expression 35

Gene Ontology 8

Phenotypes 23
Earliest

J:17077 Rudin CM, et al., Differential splicing of thymosin beta 4 mRNA. J Immunol. 1990 Jun 15;144(12):4857-62
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmsb4x:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr164585	ChrX:165993309-165993320 (-)	-1,004 bp
Tssr164584	ChrX:165992464-165992470 (-)	-156 bp
Tssr164583	ChrX:165992155-165992160 (-)	153 bp
Tssr164582	ChrX:165991561-165991611 (-)	725 bp
Tssr164581	ChrX:165990967-165991059 (-)	1,298 bp
Tssr164580	ChrX:165990955-165990963 (-)	1,352 bp
Tssr164579	ChrX:165990746-165990767 (-)	1,554 bp
Tssr164578	ChrX:165990408-165990533 (-)	1,840 bp
Tssr164577	ChrX:165990326-165990339 (-)	1,978 bp
Tssr164576	ChrX:165990278-165990290 (-)	2,027 bp
Tssr164575	ChrX:165990238-165990251 (-)	2,066 bp
Tssr164574	ChrX:165990203-165990228 (-)	2,095 bp
Tssr164573	ChrX:165990145-165990159 (-)	2,159 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24