Ccl7 MGI Mouse Gene Detail - MGI:99512 - C-C motif chemokine ligand 7

Symbol

Ccl7
Name

C-C motif chemokine ligand 7
Synonyms

fic, marc, mcp3, MCP-3, Scya7

Feature Type

protein coding gene
IDs

MGI:99512
NCBI Gene: 20306
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:81936538-81938351 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 49.83 cM
Mapping Data

6 experiments

SNPs within 2kb

163 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99512	protein coding gene	Chr11:81936538-81938351 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018822	protein coding gene	Chr11:83289745-83291558 (+)
A/J	MGP_AJ_G0018789	protein coding gene	Chr11:80088666-80090479 (+)
AKR/J	MGP_AKRJ_G0018759	protein coding gene	Chr11:82480710-82482523 (+)
BALB/cJ	MGP_BALBcJ_G0018762	protein coding gene	Chr11:80482520-80484333 (+)
C3H/HeJ	MGP_C3HHeJ_G0018576	protein coding gene	Chr11:82532734-82534547 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019214	protein coding gene	Chr11:85787932-85789745 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016848	protein coding gene	Chr11:77059530-77061330 (+)
CAST/EiJ	MGP_CASTEiJ_G0018131	protein coding gene	Chr11:83083151-83084964 (+)
CBA/J	MGP_CBAJ_G0018547	protein coding gene	Chr11:89552725-89554538 (+)
DBA/2J	MGP_DBA2J_G0018655	protein coding gene	Chr11:79649686-79651499 (+)
FVB/NJ	MGP_FVBNJ_G0018644	protein coding gene	Chr11:79197305-79199118 (+)
LP/J	MGP_LPJ_G0018725	protein coding gene	Chr11:83814057-83815870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018671	protein coding gene	Chr11:89730649-89732462 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019254	protein coding gene	Chr11:82750430-82752243 (+)
PWK/PhJ	MGP_PWKPhJ_G0017901	protein coding gene	Chr11:80475128-80476942 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017692	protein coding gene	Chr11:82361109-82362922 (+)
WSB/EiJ	MGP_WSBEiJ_G0018183	protein coding gene	Chr11:82624525-82626339 (+)

Human Ortholog

CCL7, C-C motif chemokine ligand 7

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL7, C-C motif chemokine ligand 7
Synonyms

FIC, MARC, MCP-3, MCP3, NC28, SCYA6, SCYA7
Links

HGNC:10634

NCBI Gene ID: 6354

neXtProt AC: NX_P80098

UniProt: P80098
Chr Location

17q12; chr17:34270221-34272242 (+) GRCh38

MGI Vertebrate Homology

Ccl7 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CCL7
Gene Tree

Ccl7

Diseases

1 with human CCL7 associations

				Human Disease	Mouse Models
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

4
Targeted

4
Genomic Mutations

2 involving Ccl7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a knock-out allele exhibit alterations in blood monocyte counts and in the monocytic response to thioglycollate-induced inflammation.

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All GO Annotations

30
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

852
Tissues

37
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

2
UniProt

2
CCDS

CCDS36245.1

Ensembl

ENSMUSG00000035373 (Evidence)
NCBI Gene

20306

			Length	Strain/Species	Flank
genomic	20306	NCBI Gene Model \| MGI Sequence Detail	1814	C57BL/6J	± kb
transcript	NM_013654	RefSeq \| MGI Sequence Detail	912	ZRU/MplStud
polypeptide	Q03366	UniProt \| EBI \| MGI Sequence Detail	97	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000002125 C-C motif chemokine 7

(term hierarchy)
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily
GlyGen

Q03366 1 site

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All nucleic 21

Genomic 5

cDNA 14

Primer pair 2

Microarray probesets 3

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MGD-MRK-16289

Summaries

All 93

Developmental Gene Expression 6

Gene Ontology 9

Phenotypes 29
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:352715 Kang HS, et al., GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. Cell Mol Life Sci. 2024 Jan 28;81(1):65

TSS for Ccl7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr103562	Chr11:81936363-81936384 (+)	-164 bp
Tssr103563	Chr11:81936531-81936547 (+)	1 bp
Tssr103564	Chr11:81937344-81937355 (+)	812 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24