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Cavin2 Gene Detail
Summary
  • Symbol
    Cavin2
  • Name
    caveolae associated 2
  • Synonyms
    cavin 2, Sdpr
  • Feature Type
    protein coding gene
  • IDs
    MGI:99513
    NCBI Gene: 20324
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:51328285-51342119 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    431 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99513
 protein coding gene Chr1:51328285-51342119 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016002
 protein coding gene Chr1:50788535-50802147 (+)
A/J MGP_AJ_G0015984
 protein coding gene Chr1:49073307-49087187 (+)
AKR/J MGP_AKRJ_G0015940
 protein coding gene Chr1:50116195-50131701 (+)
BALB/cJ MGP_BALBcJ_G0015941
 protein coding gene Chr1:48895468-48909311 (+)
C3H/HeJ MGP_C3HHeJ_G0015773
 protein coding gene Chr1:50505726-50520175 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016392
 protein coding gene Chr1:52940402-52956238 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014132
 protein coding gene Chr1:42756397-42769772 (-)
CAST/EiJ MGP_CASTEiJ_G0015354
 protein coding gene Chr1:49972913-49988332 (+)
CBA/J MGP_CBAJ_G0015744
 protein coding gene Chr1:54340511-54358641 (+)
DBA/2J MGP_DBA2J_G0015845
 protein coding gene Chr1:48342933-48356544 (+)
FVB/NJ MGP_FVBNJ_G0015847
 protein coding gene Chr1:47789323-47806550 (+)
LP/J MGP_LPJ_G0015916
 protein coding gene Chr1:51259601-51273144 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015867
 protein coding gene Chr1:57380993-57395503 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016440
 protein coding gene Chr1:50233826-50247616 (+)
PWK/PhJ MGP_PWKPhJ_G0015140
 protein coding gene Chr1:48208902-48223393 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014920
 protein coding gene Chr1:49898838-49912554 (+)
WSB/EiJ MGP_WSBEiJ_G0015417
 protein coding gene Chr1:50040722-50054392 (+)



Homology
more
  • Human Ortholog
    CAVIN2, caveolae associated protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAVIN2, caveolae associated protein 2
  • Synonyms
    cavin-2, PS-p68, SDPR, SDR
  • Links
    NCBI Gene ID: 8436
    neXtProt AC: NX_O95810
    UniProt: O95810

  • Chr Location
    2q32.3; chr2:191834310-191847088 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal caveolae formation in lung and adipose endothelia and adipocytes with gaps in the lung capillaries.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    39
  • cDNA Data
    78
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20324 NCBI Gene Model | MGI Sequence Detail 13835 C57BL/6J ±  kb
    transcript NM_138741 RefSeq | MGI Sequence Detail 3069 Not Specified  
    polypeptide Q63918 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 78
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16290, MGI:5896597
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:318731 Higuchi Y, et al., Requirement of Cavin-2 for the expression and stability of IRbeta in adequate adipocyte differentiation. Mol Metab. 2022 Jan;55:101416
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory