Tnr MGI Mouse Gene Detail - MGI:99516

Symbol

Tnr
Name

tenascin R
Synonyms

J1-tenascin, janusin, restrictin, TN-R

Feature Type

protein coding gene
IDs

MGI:99516
NCBI Gene: 21960
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:159351339-159759299 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.03 cM, cytoband E2
Mapping Data

3 experiments

SNPs within 2kb

10796 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99516	protein coding gene	Chr1:159351170-159759299 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016638	protein coding gene	Chr1:164676077-165105510 (+)
A/J	MGP_AJ_G0016619	protein coding gene	Chr1:157995473-158413098 (+)
AKR/J	MGP_AKRJ_G0016585	protein coding gene	Chr1:162825637-163240606 (+)
BALB/cJ	MGP_BALBcJ_G0016580	protein coding gene	Chr1:158552096-158965605 (+)
C3H/HeJ	MGP_C3HHeJ_G0016404	protein coding gene	Chr1:162998506-163416237 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017041	protein coding gene	Chr1:170284448-170730854 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014750	protein coding gene	Chr1:150159415-150569709 (+)
CAST/EiJ	MGP_CASTEiJ_G0015984	protein coding gene	Chr1:162611827-163064685 (+)
CBA/J	MGP_CBAJ_G0016379	protein coding gene	Chr1:176325184-176771710 (+)
DBA/2J	MGP_DBA2J_G0016485	protein coding gene	Chr1:156978548-157389537 (+)
FVB/NJ	MGP_FVBNJ_G0016483	protein coding gene	Chr1:155391622-155800590 (+)
LP/J	MGP_LPJ_G0016556	protein coding gene	Chr1:165790210-166218479 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016508	protein coding gene	Chr1:183849049-184280926 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017077	protein coding gene	Chr1:162656130-163069119 (+)
PWK/PhJ	MGP_PWKPhJ_G0015770	protein coding gene	Chr1:156109683-156545427 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015557	protein coding gene	Chr1:161488491-161941442 (+)
WSB/EiJ	MGP_WSBEiJ_G0016046	protein coding gene	Chr1:162816733-163244719 (+)

Human Ortholog

TNR, tenascin R

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNR, tenascin R
Synonyms

NEDSTO, TN-R
Links

HGNC:11953

NCBI Gene ID: 7143

neXtProt AC: NX_Q92752

UniProt: Q92752
Chr Location

1q25.1; chr1:175315194-175743595 (-) GRCh38

MGI Vertebrate Homology

Tnr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNR
Gene Tree

Tnr

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Tnr
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

In spite of having decreased conduction velocity in the optic nerve and ultrastrucural alterations within the hippocampus, homozygous null mice are viable, fertile, and display normal behavior.

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All GO Annotations

47
GO References

23

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

43
cDNA Data

10
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TNR

Xenbase tnr

ZFIN tnr

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All Sequences

65
RefSeq

26
UniProt

3
CCDS

CCDS15403.1

Ensembl

ENSMUSG00000015829 (Evidence)
NCBI Gene

21960

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015829	Ensembl Gene Model \| MGI Sequence Detail	407961	C57BL/6J	± kb
transcript	ENSMUST00000192069	Ensembl \| MGI Sequence Detail	12202	Not Applicable
polypeptide	ENSMUSP00000141553	Ensembl \| MGI Sequence Detail	1358	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000016516 tenascin-R

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR013111 EGF-like domain, extracellular

IPR050991 Extracellular Matrix Regulatory Proteins

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1

IPR036056 Fibrinogen-like, C-terminal

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR041161 Tenascin, EGF-like domain
GlyGen

Q8BYI9 18 sites, 46 N-linked glycans (11 sites), 4 O-linked glycans (1 site)

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All nucleic 11

cDNA 10

Primer pair 1

Microarray probesets 1

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MGD-MRK-16293

Summaries

All 82

Developmental Gene Expression 7

Gene Ontology 23

Phenotypes 44
Earliest

J:314849 Pesheva P, et al., J1-160 and J1-180 are oligodendrocyte-secreted nonpermissive substrates for cell adhesion. J Cell Biol. 1989 Oct;109(4 Pt 1):1765-78
Latest

J:351222 Reinhard J, et al., Neural extracellular matrix regulates visual sensory motor integration. iScience. 2024 Feb 16;27(2):108846

TSS for Tnr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr9622	Chr1:159351338-159351443 (+)	52 bp
Tssr9623	Chr1:159351446-159351465 (+)	117 bp
Tssr9624	Chr1:159436333-159436336 (+)	84,996 bp
Tssr9625	Chr1:159753623-159753635 (+)	402,290 bp
Tssr9626	Chr1:159753803-159753822 (+)	402,474 bp
Tssr9627	Chr1:159758635-159758646 (+)	407,302 bp
Tssr9628	Chr1:159758650-159758662 (+)	407,317 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24