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Mef2a Gene Detail
Summary
  • Symbol
    Mef2a
  • Name
    myocyte enhancer factor 2A
  • Synonyms
    A430079H05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:99532
    NCBI Gene: 17258
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:66880911-67022606 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 36.72 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2204 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99532
 protein coding gene Chr7:66880911-67026435 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032358
 protein coding gene Chr7:68480080-68624635 (-)
A/J MGP_AJ_G0032337
 protein coding gene Chr7:67074194-67214474 (-)
AKR/J MGP_AKRJ_G0032273
 protein coding gene Chr7:68493585-68632107 (-)
BALB/cJ MGP_BALBcJ_G0032349
 protein coding gene Chr7:66808932-66951436 (-)
C3H/HeJ MGP_C3HHeJ_G0032062
 protein coding gene Chr7:69183121-69325003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032841
 protein coding gene Chr7:71418143-71572481 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029848
 protein coding gene Chr7:69951455-70074359 (-)
CAST/EiJ MGP_CASTEiJ_G0031390
 protein coding gene Chr7:59870341-60015577 (-)
CBA/J MGP_CBAJ_G0032028
 protein coding gene Chr7:73659634-73809259 (-)
DBA/2J MGP_DBA2J_G0032183
 protein coding gene Chr7:65793241-65933553 (-)
FVB/NJ MGP_FVBNJ_G0032138
 protein coding gene Chr7:65911823-66052881 (-)
LP/J MGP_LPJ_G0032264
 protein coding gene Chr7:69707272-69849205 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032175
 protein coding gene Chr7:73860266-74032517 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032859
 protein coding gene Chr7:67852222-67998341 (-)
PWK/PhJ MGP_PWKPhJ_G0031110
 protein coding gene Chr7:58842285-58978877 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030951
 protein coding gene Chr7:54903387-55040741 (-)
WSB/EiJ MGP_WSBEiJ_G0031508
 protein coding gene Chr7:68198348-68333087 (-)



Homology
more
  • Human Ortholog
    MEF2A, myocyte enhancer factor 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEF2A, myocyte enhancer factor 2A
  • Synonyms
    ADCAD1, mef2, RSRFC4, RSRFC9
  • Links
    NCBI Gene ID: 4205
    neXtProt AC: NX_Q02078
    UniProt: Q02078

  • Chr Location
    15q26.3; chr15:99565417-99716488 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MEF2A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene results in cardiac sudden death. Mice dying in the early postnatal period exhibit ventricular dilation, while mice dying in adulthood show a reduced number of mitochondria in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1058
  • Tissues
    268
  • cDNA Data
    21
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030557 Ensembl Gene Model | MGI Sequence Detail 141696 C57BL/6J ±  kb
    transcript ENSMUST00000156690 Ensembl | MGI Sequence Detail 5538 Not Applicable  
    polypeptide ENSMUSP00000117496 Ensembl | MGI Sequence Detail 498 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 23
      Primer pair 8
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-16310, MGI:2445167
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 40
      Gene Ontology 28
      Phenotypes 38
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:338901 Boogerd CJ, et al., Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation. Nat Commun. 2023 Aug 5;14(1):4716
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory